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原创 Linear Regression(Chapter 6)[@XiruChen]
OutlinesData, Model and AssumptionsParameter estimationImportant statistics and distributionMultivariate linear regressionData, Model and AssumptionsDatann observations: (X1,Y1),(X2,Y2),...,(Xn,Yn
2015-04-01 22:35:07 306
原创 Plan of 2015
Keywordsplan & summary writing;Reading book/paper;Project;Drug Development;English;RequirementsWrite week plan and week summary! Obey the tomato working protocol~Book list of 2015Probability an
2015-03-31 18:20:16 281
原创 Multivariate Analysis ch1 (Overview)
This is the note of book “Applied multivariate methods for data analysts”1.Outlines:Data: Response Variable v.s. Experimental Units;Type of Methods: Variable-directed techinique v.s. Individual-direc
2015-03-12 23:38:58 431
原创 CCA(gwas)
This is a short review of a multivariate test of associations[@ferreira2009multivariate] implemented in PLINK[@Purcell2007559].Remained Questions:Derivation of the statistics still don’t understand;C
2015-03-11 15:36:37 586
原创 Permutation test
Outlines:Goals and strategyThe simple conditionThe complex conditionGoals and strategyGoals:Estimate the distribution of the test statistic(TT) under the null hypothesis, thus the p-value of the o
2015-03-11 13:23:37 1013
原创 Fisher Information
1. The Likelihood似然函数: 设XX的p.d.f.为f(x;θ)f(x;\theta),其中θ\theta为参数,i.i.d.样本X˜=(X1,...,Xn)\widetilde{X}=(X_1,...,X_n),那么似然函数为: L(θ;x˜)=∏i=1nf(xi;θ).L(\theta;\widetilde{x})= \prod_{i=1}^n f(x_i;\theta).
2015-03-11 13:20:49 6594 1
原创 Interval estimation (Section 4.4)[@XiruChen]
0. Outlines区间构造原则置信系数;区间估计方法简介:(Confidence Interval v.s. Critical Interval)[@wiki_CI] 小样本估计法(枢轴量法)大样本估计法(近似正态) 非参数bootstrap法贝叶斯方法区间估计的评估1. 区间估计构造原则对于构造的估计区间[θ^1(X1,...,Xn),θ^2(X1,...,Xn)][\hat
2015-03-11 13:18:36 366
原创 Hypothesis Testing(Chapter 5)[@XiruChen]
0. Outlines1. 基本概念假设,检验统计量,拒绝域;功效函数;两类错误,检验的水平;假设检验的优良性准则(一致最优检验);p-值;2. 重要的参数检验连续型随机变量:正态总体均值的检验;两正态总体均值差的检验;正态总体方差的检验(一个总体&两个总体);指数分布参数的检验;离散型随机变量二项分布参数pp的检验(符号检验);泊松分布参数λ\lambda的检验;大样本
2015-03-11 13:18:29 643
原创 Probability and statistics (part I)
第一章 事件的概率第二章 随机变量及概率分布随机变量的函数的概率分布正态分布由均匀分布U(0,1)产生任意分布F(x):第三章 随机变量的数字特征3.1. 期望期望的性质:(性质优良)条件期望3.2. 中位数 link3.3. 方差和矩3.4. 协方差,相关系数3.5 累积量κn(cumulants)3.6 大数定理/定律和中心极限定理
2015-03-11 11:53:12 653
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