I was trying to remotely connect to a Windows 10 laptop with Remmina from a Ubuntu 18.04 Beta desktop. Connection failed with error "Unable to connect to RDP server".
After confirming the IP/Username/Password/Domain for Windows is correct, I googled and found the following fix:
$ vim ./.config/freerdp/known_hosts
Find and delete the line that has the IP you are connecting to, then re-connect from Remmina.
Alternatively, you can delete the file "known_hosts" which also could fix this issue:
$ rm ./.config/freerdp/known_hosts