解决办法:
在列的绑定属性里加上UpdateSourceTrigger,示例XAML如下
<DataGrid Grid.Row="1" Height="274" HorizontalAlignment="Left" Margin="12,10,0,0" Name="dataGrid2" VerticalAlignment="Top" Width="679" RowEditEnding="dataGrid2_RowEditEnding" AutoGenerateColumns="False">
<DataGrid.Columns>
<DataGridTextColumn Header="姓名" Width="*" Binding="{Binding Name,Mode=TwoWay,UpdateSourceTrigger=PropertyChanged}"/>
<DataGridTextColumn Header="地址" Width="*" Binding="{Binding Addr,Mode=TwoWay,UpdateSourceTrigger=PropertyChanged}"/>
</DataGrid.Columns>
</DataGrid>