In an Age of Images, Teaching Pathology by Hand

原创 2007年09月13日 15:50:00

BOSTON — The patient’s decline was ruthless. He became forgetful in his early 50s. By the time he saw a neurologist a few years later, he could not recall how to write in cursive, and confused pictures of a cookie and a whistle, a bed and a sandbox.

Skip to next paragraph
Photographs by Robert Spencer for The New York Times

Dr. Jeffrey T. Joseph, a pathologist, leading a first-year resident, Dr. Scott Wenson, above left, through a brain autopsy at the Beth Israel Deaconess Medical Center at Harvard. “It’s part diagnosis, part entertainment,” Dr. Joseph said of his neuropathology seminar.

A few years after that, he could no longer dress himself or speak fluently, and had developed muscle jerks that required medication to control. Diagnostically, he showed symptoms of several types of dementia, but no hallmarks that would narrow the cause to only one. He died in his early 60s.

On a Friday morning a week later, Dr. Jeffrey T. Joseph, a pathologist, was gazing at the patient’s brain, waiting for neurology residents to arrive and gaze with him. He pondered whether to begin the dissection with a traditional vertical slice down the height of the brain. “I might cut coronally, might cut horizontally,” he said, thoughtfully. “I haven’t decided yet.”

From a distance, brain autopsies seem an afterthought on life. Insurance does not cover them. They serve no lucrative purpose, so hospitals have a financial disincentive to do them. As a result, the field of neuropathology is shrinking, and its atrophy may diminish the entire field of neurology.

Neurology, after all, is a subscience of anatomy — the symptoms of brain disorders are directly related to the sites of lesions — yet many neurology residencies no longer require brain-cutting time. Without this experience, residents cannot lay eyes or hands on the organ that will be their lifeblood.

“Neuropathology as a freestanding subspecialty is going to disappear,” said Dr. Thomas Smith, professor of pathology and neurology at University of Massachusetts Medical School. “It’s going to be subsumed into general surgical pathology.” His department used to have two neuropathologists and a lab; now there is no lab and one doctor.

“If you don’t have a neuropathologist on your faculty teaching, it’s a big loss,” Dr. Smith added.

A few generations ago, neurologists in training spent months dissecting spinal cords and brains. “The main reason,” said Dr. Dan Press, assistant professor of neurology at Harvard Medical School (and a former student of Dr. Joseph’s, who still attends the seminars when he can), “was because there was no imaging then.”

Everything changed with the advent of magnetic resonance imaging. Now residents spend hours each week studying neuroradiology; M.R.I. and CT are the primary educational tools. As a result, they gain most of their anatomical knowledge from images. Specialty board examinations that used to be full of pathology pictures are now full of radiologic images.

“But pathology still allows a resolution that imaging never will,” Dr. Press said. “It forces you to see three-dimensionally. There’s no more concrete way to make it real. It’s the difference between looking at maps of a place and driving around it.”

Dr. Joseph has conducted a weekly neuropathology seminar at the Beth Israel Deaconess Medical Center at Harvard for more than 12 years. In the fall, he will leave Harvard to become a professor at the University of Calgary in Alberta. His seminar will move with him. “It’s part diagnosis, part entertainment,” Dr. Joseph said. “I like to make them look. The brain is like a geode — you don’t know what’s inside.”

A lively 52-year-old with sideburns and a Mephistophelean glint, Dr. Joseph wears a bow tie covered with dragons, or paramecia; he does not know which, because his wife — a neurologist who attended his seminar during her residency — buys them.

The autopsy suite is in the basement of the hospital, behind an unmarked door with a discreet posting: “Funeral directors, please sign the log book.” Unlike the surgical pathology suite, where there are five high-grade cutting stations, the atmosphere here is left-behind; ventilation is old and loud, and sometimes it can be hard to find a pair of sharp scissors. Bach used to play in the background, until a senior pathologist remonstrated Dr. Joseph that the autopsy suite was not a place for music; it was sacred ground, a church. Dr. Joseph pointed out that Bach was often played in churches. The argument did not prevail.

Residents drift in — neurology tuning forks and reflex hammers poking from white pockets — and move toward the dissecting table, where blades and tweezers have been laid out beside several bulging towels in pans. Dr. Press is here, too; he was one of the physicians caring for the patient. Dr. Joseph unwraps one of the towels. It is the control case, a normal brain from a patient who died of unrelated illness.

“Nice and full,” Dr. Joseph says. “You see the gyri. We’ll compare him to No. 2.”

An Introduction to Interactive Programming in Python (Part 2) week 6 (Classes and Tied images)

Objects, classes and their terminology — Object-oriented programming All data entities in Python ar...

《Interactive graph cuts for optimal boundary & region segmentation of objects in N-D images》读后感及问题

N维图像基于最优边界和区域分割的交互式图割 用户通过交互式选择图像的某部分作为“目标”和“背景”,然后分割方法基于用户定义的“目标”和“背景”硬性约束,定义一个包含区域和边界信息的能量函数,该能量函...
  • jpday
  • jpday
  • 2015年12月13日 11:29
  • 1985

图割论文阅读笔记:Interactive Graph Cuts for Optimal Boundary & Region Segmentation of Objects in N-D Images

Interactive Graph Cuts for Optimal Boundary & Region Segmentation of Objects in N-D Images翻译总结下这篇文章,...

Detecting Texts of Arbitrary Orientations in Natural Images(总结)

Lazy loading of images in Listview L...

1.4 Dynamically change the look of an application by using view states,transitions and effects

您举报文章:In an Age of Images, Teaching Pathology by Hand