When I run my ASP.NET MVC 4 website on my ubuntu 14.04 LTS with xsp4 (from MonoDevelop or directly) I'm getting the following exception:
Access to the path "/etc/mono/registry" is denied.
Turns out simply creating the folder using mkdir
sudo mkdir /etc/mono/registry
and setting the right permissions using chmod
sudo chmod uog+rw /etc/mono/registry
does the trick.