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MERINGUE是一种基于空间自相关和交叉相关分析的计算框架，旨在识别具有空间异质性表达模式的基因，适用于非均匀细胞密度的组织。它能够进行空间细胞聚类，并推断细胞间的潜在通讯，适用于多种空间分辨率的单细胞转录组学数据。
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文章目录
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- Characterizing spatial gene expression heterogeneity in spatially resolved single-cell transcriptomics data with non-uniform cellular densities
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- Abstract
- Introduction
- Results
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- Overview of MERINGUE
- MERINGUE identifies genes with spatially heterogeneous expression patterns and is robust to changes in cellular densities
- MERINGUE integrates 3D and multi-layer tissue information
- MERINGUE identifies spatial patterns in the mouse hypothalamic preoptic region using spatially resolved single-cell gene expression data by MERFISH
- Spatially informed clustering identifies transcriptionally and spatially distinct subtypes of cells
- MERINGUE identifies putative cell-cell communication between cell-types
- Discussion
Characterizing spatial gene expression heterogeneity in spatially resolved single-cell transcriptomics data with non-uniform cellular densities
Authors：Brendan F. Miller, Dhananjay Bambah-Mukku, Jean Fan, et al.
Journal：Genome Research
Year：2021
DOI：10.1101/gr.271288.120
Keywords：spatial transcriptomics, single-cell transcriptomics, bioinformatics, heterogeneity, cellular communication, expression patterns
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