Nirsevimab 是一种重组人呼吸道合胞病毒 (RSV) 单克隆抗体，具有修饰的 Fc 区，可延长其半衰期 | MedChemExpress (MCE)

Nirsevimab

CAS：1989556-22-0

品牌：MedChemExpress (MCE)

存储条件：Please store the product under the recommended conditions in the Certificate of Analysis.

生物活性：Nirsevimab (MEDI8897) 是一种重组人呼吸道合胞病毒 (RSV) 单克隆抗体，具有修饰的 Fc 区，可延长其半衰期。Nirsevimab 对 RSV-B 具有亲和力，Kd 值为 1.5 nM。Nirsevimab 可用于 RSV 研究。

参考文献：

[1]. Griffin MP, et al. Single-Dose Nirsevimab for Prevention of RSV in Preterm Infants. N Engl J Med. 2020 Jul 30;383(5):415-425.
[2]. Griffin MP, et al. Safety, Tolerability, and Pharmacokinetics of MEDI8897, the Respiratory Syncytial Virus Prefusion F-Targeting Monoclonal Antibody with an Extended Half-Life, in Healthy Adults. Antimicrob Agents Chemother. 2017 Feb 23;61(3):e01714-16.
[3]. Cabán M, et al. Cross-protective antibodies against common endemic respiratory viruses. Nat Commun. 2023 Feb 13;14(1):798.