signature=7977387978f17dafd07ee4c7d63dbd29,CHITIN BINDING PROTEINS AND METHODS OF USE

本文揭示了通过接触一种或多种CBPs来增加上皮细胞(如肠道上皮细胞)增殖的方法。这些方法包括向需要增加上皮细胞增殖的个体施用CBP。此外,还介绍了鉴定具有或可能发展为上皮细胞过度增殖风险的个体的方法,以及通过降低CBP表达和/或活性来减少上皮细胞增殖的方法。同时,还涉及寻找抑制上皮细胞增殖和/或CBP活性的抑制剂的手段。
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摘要:

Disclosed herein are methods of increasing epithelial cell proliferation (such as intestinal epithelial cell proliferation) by contacting epithelial cells with one or more CBPs. In some examples, the methods include administering the CBP to a subject, such as a subject in need of increased epithelial cell proliferation. Also disclosed herein are methods of identifying a subject having or at risk of developing hyperproliferation of epithelial cells (such as intestinal epithelial cells). Further disclosed are methods of decreasing epithelial cell proliferation by decreasing expression and/or activity of a CBP and methods of identifying inhibitors of epithelial cell proliferation and/or CBP activity.

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