In test/development environments
The werkzeug debugger already has an 'auto reload' function available that can be enabled by doing one of the following:
app.run(debug=True)
or
app.debug = True
You can also use a separate configuration file to manage all your setup if you need be. For example I use 'settings.py' with a 'DEBUG = True' option. Importing this file is easy too;
app.config.from_object('application.settings')
However this is not suitable for a production environment.
Production environment
Personally I chose Nginx + uWSGI over Apache + mod_wsgi for a few performance reasons but also the configuration options. The touch-reload option allows you to specify a file/folder that will cause the uWSGI application to reload your newly deployed flask app.
For example, your update script pulls your newest changes down and touches 'reload_me.txt' file. Your uWSGI ini script (which is kept up by Supervisord - obviously) has this line in it somewhere:
touch-reload = '/opt/virtual_environments/application/reload_me.txt'
I hope this helps!