signature=135ccaca816ddee6720f30c194fd4223,RAD51G135C 和XRCC3C241T基因型与急性髓系白血病疗效及预后相关性研究...-CSDN博客

abstracts：

Objective To investigate the impacts of RAD51G135C and XRCC3C241T genotypes on the response,adverse effects,and prognosis of acute myelocytic leukemia(AML).Methods RAD51 G135C,XRCC3 C241T,GSTF1,and GSTM1 genotypes were analyzed in 372 patients with AML,226 males and 146 females,by PCR-RFLP or PCR.The Complete remission(CR)rate,adverse effects,overall survival (OS),and relapse-free survival(RFS)were compared among the groups with different genotypes.Results (1)During the induction chemotherapy,XRCC3 C241T polymorphic allele was significantly associated with the shorter survival of the AML patients with t(t5;17)/PML-RARα(OR=8.750,P=0.046).Among the non-M3 patients,the complete remission(CR)rate of those with double RAD51G135C and GSTTl wild genotypes was 71.6%,significantly higher than that of those not with double RAD51 G135C and GSTF1 wild genotypes(54.4%,P=0.028).(2)The OS of the non-M3 AML patients with double RAD51G135C and GSTT1 wild genotypes was(39.1±7.1)months,significantly longer than those with double variant types [(22.4±3.2)months,P=0.042].The relapse-free survival(RFS)of the M4EO and M2 patients with double XRCC3C241T and GSTT1 wild type genotype were 48.3 months and 56.5 months,both significantl ylonger than those of the patients with double variant genotypes(28.8 months and 10.0 months respectively,both P＜0.05).The OS of the M2 patients with triple RAD51 G135C,GSqT1,and GSTM1 variant genotypes was(22.4±3.2)months,significantly shorter than those with triple RAD51 G135C,GSTT1,and GSTM1 wild genotypes[(39.1±7.1)months,P=0.042].The RFS of the M2 patients with triple RAD51 G135C,GSTT1,and GSTM1 variant genotypes was 10.0 months,significantly shorter than that of the patients with triple RAD51 G135C,GSTY1,and GSTM1 wild genotypes(64.2 months,P=0.015).(3)The risk levels of neutropenia,nausea and vomiting,and alopecia of the patients with variant XRCC3 C241T genotype were all significantly higher than those of the wild type genotype(all P＜0.05).The risk of hematuria of the patients with variant genotype was significantly higher than that of the patients with wild genotype(P=0.017).Conclusion The polymorphisms of XRCC3C241T and RAD51 G135C genes are significantly related to response to therapy,adverse effects,and prognosis of AML.Detection of the XRCC3C241T and RAD51 G135C genotypes may be useful in selecting individual chemotherapy regimens for patients with AML.