signature=99f911bba99fe483c7d62f4b779059a0,Metabolic signatures of Huntington's disease (HD): 1H NMR...

摘要：

•First reported study to use1H NMR based metabolomics to investigate HD in the striatum and frontal lobe of PM human brain•Models capable of accurately discriminating between control and HD cases•The concentrations of 15 metabolites in the striatum and 4 in the frontal lobe were affected in HD brain.•Potential for using metabolites as state biomarkers of HD using in vivo MRS technologies•Identification of previously unknown front-striatal perturbations associated with HD

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