Just do a clean install of Windows Server 2008 R2 x64, do NOT configure your server yet, do NOT install any updates.
Use the correct and only certified install source from: http://www.oracle.com/technetwork/database/10204-winx64-vista-win2k8-082253.html "10204_vista_w2k8_x64_production_db.zip"
Unpack and open a command prompt in the "..\database" directory where the "setup.exe" is located.
Run the following command: setup.exe -ignoreSysprereqs
Wait for the OUI windows and continue with your preferences selections.
When the OUI prerequisites window appear it will come with the following error:
INFO: The user has manually verified 'Checking operating system requirements ...'
INFO: Checking CertifiedVersions
This is a prerequisite condition to test whether the Oracle software is certified on the current O/S.
INFO: Expected result: One of 5.0,5.1,5.2,6.0
Actual Result: 6.1
Check complete. The overall result of this check is: Failed <<<<
Select the checkbox to bypass the error and continue installation
Download and unpack the 10.2.0.5 Patch Set from My Oracle Support and install it.
Have fun with you Oracle 10g x64 on a Windows Server 2008 R2 x64!
Regards,
Maurice