Hello Sylvia,
Thank you for posting your query in Microsoft Community.
We regret the inconvenience caused to you. We will be glad to assist you with the issue.
You may try the steps as below and check if the issue gets fixed.
Note DDE is Dynamic data exchange and the Explorer uses DDE to open Office documents (supposed you open the document from the explorer window).
DDE Share is a tool for managing the way programs communicate and share data over a network.
If you wish to disable this prompt then you may follow the below steps.
Here, this issue could occur if you have installed any security program on your computer you may get this error message.
Tryto turn off the on-access scanning for the application control policy in your security program and check for the issue.
To do that you need to contact your security program support team.
For further information on this you may visit the below links.
Let us know the status of the issue. We will be glad to assist you further.
Thank you.