using System;
using System.Collections.Generic;
using System.ComponentModel;
using System.Data;
using System.Drawing;
using System.Linq;
using System.Text;
using System.Windows.Forms;
using System.Data.OleDb;
using Microsoft.Office;
private void SaveFile_Click(object sender, EventArgs e)
{
    try
    {
        #region   验证可操作性
        //申明保存对话框  
        SaveFileDialog dlg = new SaveFileDialog();
        //默然文件后缀  
        dlg.DefaultExt = "xls ";
        //以当前时间作为默认文件名
        dlg.FileName = DateTime.Now.ToString("yyyymmddhhmmss") + "CustomerData";
        //文件后缀列表  
        dlg.Filter = "EXCEL文件(*.XLS)|*.xls ";
        //默然路径是系统当前路径  
        dlg.InitialDirectory = "D:/";
        //打开保存对话框  
        if (dlg.ShowDialog() == DialogResult.Cancel) return;
        //返回文件路径  
        string fileNameString = dlg.FileName;
        //验证strFileName是否为空或值无效  
        if (fileNameString.Trim() == " ")
        { return; }
        //定义表格内数据的行数和列数  
        int rowscount = dataGridView1.Rows.Count;
        int colscount = dataGridView1.Columns.Count;
        //行数必须大于0  
        if (rowscount <= 0)
        {
            MessageBox.Show("没有数据可供保存 ", "提示 ", MessageBoxButtons.OK, MessageBoxIcon.Information);
            return;
        }
        //列数必须大于0  
        if (colscount <= 0)
        {
            MessageBox.Show("没有数据可供保存 ", "提示 ", MessageBoxButtons.OK, MessageBoxIcon.Information);
            return;
        }
        //行数不可以大于65536  
        if (rowscount > 65536)
        {
            MessageBox.Show("数据记录数太多(最多不能超过65536条)，不能保存 ", "提示 ", MessageBoxButtons.OK, MessageBoxIcon.Information);
            return;
        }
        //列数不可以大于255  
        if (colscount > 255)
        {
            MessageBox.Show("数据记录行数太多，不能保存 ", "提示 ", MessageBoxButtons.OK, MessageBoxIcon.Information);
            return;
        }
        #endregion
        Microsoft.Office.Interop.Excel.Application objExcel = null;
        Microsoft.Office.Interop.Excel.Workbook objWorkbook = null;
        Microsoft.Office.Interop.Excel.Worksheet objsheet = null;
        try
        {
            //申明对象  
            objExcel = new Microsoft.Office.Interop.Excel.Application();
            objWorkbook = objExcel.Workbooks.Add(true);
            objsheet = (Microsoft.Office.Interop.Excel.Worksheet)objWorkbook.ActiveSheet;
            //设置EXCEL不可见  
            objExcel.Visible = false;
            //向Excel中写入表格的表头  
            int displayColumnsCount = 1;
            for (int i = 0; i <= dataGridView1.ColumnCount - 1; i++)
            {
                if (dataGridView1.Columns[i].Visible == true)
                {
                    objExcel.Cells[1, displayColumnsCount] = dataGridView1.Columns[i].HeaderText.Trim();
                    displayColumnsCount++;
                }
            }
            //向Excel中逐行逐列写入表格中的数据  
            for (int row = 0; row <= dataGridView1.RowCount - 1; row++)
            {
                displayColumnsCount = 1;
                for (int col = 0; col < colscount; col++)
                {
                    if (dataGridView1.Columns[col].Visible == true)
                    {
                        try
                        {
                            if (dataGridView1.Rows[row].Cells[col].Value != null)
                            {
                                objExcel.Cells[row + 2, displayColumnsCount] = "'" + dataGridView1.Rows[row].Cells[col].Value.ToString();
                            }
                            else
                            {
                                objExcel.Cells[row + 2, displayColumnsCount] = "";
                            }
                            displayColumnsCount++;
                        }
                        catch (Exception ex)
                        {
                            MessageBox.Show(ex.Message);
                        }
                    }
                }
            }
            //保存文件  
            objWorkbook.SaveAs(fileNameString, true, null, null, null,
                    null, Microsoft.Office.Interop.Excel.XlSaveAsAccessMode.xlShared, true, true, true,
                    true, true);
            objExcel.Quit();
        }
        catch (Exception error)
        {
            MessageBox.Show(error.Message, "警告 ", MessageBoxButtons.OK, MessageBoxIcon.Warning);
            return;
        }
    }
    catch (Exception ex)
    {
        MessageBox.Show(ex.Message, "错误提示");
    }  
}

这个代码大部分都可以很容易看懂，难点就是objWorkbook.SaveAs（）这个函数，其实这个函数是一个缩写，其完整格式为：Microsoft.Office.Interop.Excel.Workbook.SaveAs（Filename, FileFormat, Password, WriteResPassword, ReadOnlyRecommended, CreateBackup, AccessMode, ConflictResolution, AddToMru, TextCodepage, TextVisualLayout, Local），其中第三个Password是设置打开excel时的密码，不用时可写null，WriteResPassword是当要编辑时的密码，不用时写null，ReadOnlyRecommended是设置只读操作，不用时写null，CreateBackup是启动备份，当启用时，一旦修改了excel，就会自动对先前的数据进行保存，不用时写null。