详细内容参考此网址:http://social.msdn.microsoft.com/Forums/en-US/ec93922a-fd1e-4225-b5cf-1472ebb3acd1/systemsecuritycryptographycryptographicexception-the-system-cannot-find-the-file-specified?forum=netfxbcl。 摘要: 确定数字证书文件是否存在。如果宿主是 IIS,做如下配置:Open IIS7 --> ApplicationPools --> YourAppPool -->RighClikck --> Advanced Settings ---> Load User Profile set this value to true。