不需要修改apache 的主配置文件，直接修改 vhosts文件添加入下内容即可


<VirtualHost *:80>
ServerAdmin 101.227.253.218
DocumentRoot "E:/asd"        #E盘下空的目录
<Directory "E:/asd">          #E盘下空的目录
AllowOverride None
Order Deny,Allow
Allow from 127.0.0.1
</Directory>
</VirtualHost>

<VirtualHost *:80>
ServerAdmin 101.227.253.218
Servername www.science-mall.com        #我的域名
DocumentRoot "E:/xampp/htdocs"          #真实网站程序  
<Directory "E:/xampp/htdocs/">          #真实网站程序
Options Indexes FollowSymLinks Includes ExecCGI    #下面这三条是复制主配置的
AllowOverride All
  Require all granted
</Directory>
</VirtualHost>