2月11日，由于.Net framework 4、4.5、4.5.1已经停止支持（https://blogs.msdn.microsoft.com/dotnet/2015/12/09/support-ending-for-the-net-framework-4-4-5-and-4-5-1/），

有人提到是否可以为Exchange Server安装最新的.Net Framework 4.6.1，产品组的回应如下：

We wanted to post a quick note to call out that since yesterday, the .NET Framework 4.6.1 has been made a recommended update on WU (Windows Update).

As we have already stated in the Exchange Supportability Matrix, at this time, this version of .NET framework is not supported by Exchange. In fact, we know of some issues if it is installed.

We are working with the .NET team to ensure that Exchange customers have a smooth transition to .NET Framework 4.6.1, but in the meantime, delay this particular .NET update on your Exchange servers (information on how this can be accomplished can be found in the KB article 3133990, How to temporarily block the installation of the .NET Framework 4.6.1).

总的来讲就是产品组尚未验证完两个产品的兼容性，不确定是否还会存在潜在的issues，提醒广大管理员在使用WSUS或者windows update给Exchange Server打补丁的时候注意一下这个。

另：参考Exchange Server的兼容性矩阵：https://technet.microsoft.com/zh-cn/library/ff728623(v=exchg.150).aspx

另2：Exchange 2010与.Net Framework4.0的老问题：https://social.technet.microsoft.com/Forums/en-US/521a346d-48c3-4231-a274-b14d1176ec9e/owa-broke-after-installing-net-framework-40?forum=exchange2010