摘要:
Viral nucleic acids are major signatures of invading viruses,and their recognition by various cellular pattern recognition receptors(PRRs) represents the first step towards efficient innate immune response to clear the viruses.Sensing of viral nucleic acids and signaling by the PRRs not only involves recruitment of distinct signaling components,but are also intensively regulated by cellular organelle trafficking and posttranslational modifications.In this talk,I will focus on our recent findings on recognition of viral nucleic acids by a novel co-sensor,and regulation of innate antiviral response by organelle trafficking and posttranslational modifications.
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