中国科学院计算机研究所李林,李林-中国科学院大学-UCAS

发表论文

(1) Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors, Cancer Cell, 2020, 通讯作者(2) CARF promotes spermatogonial self-renewal and proliferation through Wnt signaling pathway, Cell Disc., 2020, 通讯作者(3) DKK2 imparts tumor immunity evasion through beta-catenin independent suppression of cytotoxic immune cell activation, Nature Medicine, 2018, 通讯作者(4) Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity, Cell Disc., 2017, 通讯作者(5) Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation, J. Biol. Chem., 2016, 通讯作者(6) A Genome-wide Loss-of-function Screening Method for Minimizing False-negatives caused by Functional Redundancy, Cell Res, 2016, 通讯作者(7) Design, Synthesis, and Structural Optimization of Lycorine-Derived Phenanthridine Derivatives as Wnt/β-Catenin Signaling Pathway Agonists, Journal of Natural Products, 2016, 通讯作者(8) Axin PPI Networks: New Interacting Proteins and New Targets?, Current Topics In Medicinal Chemistry, 2016, 通讯作者(9) Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling, J Biol Chem., 2014, 通讯作者(10) Thymine DNA glycosylase promotes transactivation of β-catenin/TCFs by cooperating with CBP, J Mol Cell Biol., 2014, 通讯作者(11) Smurf1-mediated axin ubiquitination requires Smurf1 C2 domain and is cell cycle-dependent, J Biol Chem., 2014, 通讯作者(12) New insights into the regulation of Axin function in canonical Wnt signaling pathway, Protein Cell., 2014, 通讯作者(13) Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction, Nature Chem. Biol., 2013, 通讯作者(14) Smurf1-mediated Lys29-linked non-proteolytic poly-ubiquitination of Axin negatively regulates Wnt/β-catenin signaling, Mol. Cell Biol., 2013, 通讯作者(15) The E3 Ubiquitin Ligase ITCH Negatively Regulates Canonical Wnt Signaling by Targeting Dishevelled Protein, Mol Cell Biol., 2012, 通讯作者(16) Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation, PNAS, 2011, 通讯作者(17) A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/-catenin signaling and colon cancer cell tumorigenesis, Cell Res., 2011, 通讯作者(18) Nuclear Factor of Activated T Cell (NFAT) Proteins repress canonical Wnt signaling via its interaction with dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation, J. Biol. Chem., 2011, 通讯作者(19) Dishevelled interacts with p65 and acts as a repressor of NF-B mediated transcription, Cell Res., 2010, 通讯作者(20) TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling, J. Biol. Chem, 2010, 通讯作者(21) Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5, J. Biol. Chem., 2009, 通讯作者(22) Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl, J. Biol. Chem., 2009, 第 2 作者(23) The TAK1-JNK cascade is required for IRF3 function in the innate immune response, Cell Res., 2009, 通讯作者(24) Identification of zinc-finger bed domain containing 3 (ZBED3) as a novel axin-interacting protein that activates Wnt/-catenin signaling, J. Biol. Chem., 2009, 通讯作者(25) Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation, J Cell Biol., 2008, 通讯作者(26) Nuclear Dvl, c-Jun, -catenin and TCF form a complex leading to stabilization of -catenin/TCF interaction, J Cell Biol., 2008, 通讯作者