神舟微型计算机hfmpbvx2,Reactive oxygen species and progression of metastasis of VX2 carcinoma implanted in ...

摘要：

We examined the electron spin resonance (ESR) spectra, tissue superoxide dismutase (SOD) activity, and the capacity of neutrophils to produce active oxygen in a liver metastasis model of VX2 carcinoma. The ESR spectra were similar to the signal of the oxygen radical recognized in liver tissue subjected to transcatheter hepatic arterial embolization. The signal intensity was lower in the metastatic than in the non-metastatic region, and there was a significant difference between the regions 2 weeks after the injection of the carcinoma cells. There were no differences between the SOD activity of the metastatic and non-metastatic regions, assayed weekly. The capacity of neutrophils to produce active oxygen decreased with the progression of metastasis. Our results suggest that the injection of VX2 carcinoma cells into the portal vein induces ischemia after injection. Metastatic cancer cells generated active oxygen (endogenous), at levels that were virtually constant, from 2 to 4 weeks after the injection of cancer cells. After the injection, the progress of metastasis was affected by endogenous active oxygen and by the capacity of neutrophils to produce active oxygen.

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