李国亮 【教授】 姓名李国亮性别男
职称教授学位博士
电话 **邮箱guoliang.li@mail.hzau.edu.cn
工作单位信息学院，作物遗传改良国家重点实验室
研究方向三维基因组学，计算生物学，生物信息学，新一代DNA序列数据分析
教育经历1990.9－1994.7西安交通大学自动控制专业学士
1998.9－2001.6中科院自动化所自动控制专业硕士
2001.7－2002.6新加坡－麻省理工学院学术联盟计算机专业硕士
2003.1－2009.7新加坡国立大学计算学院
主要职历1994.7－1998.8西安六一八研究所助理工程师
2002.8－2005.3新加坡国立大学计算学院研究助理(ResearchAssistant)
2008.1－2008.12新加坡国立大学计算学院助教(TeachingAssistant)
2009.1－2012.3新加坡基因组研究院博士后(Post-DoctoralFellow)
2012.4－2012.12新加坡基因组研究院副研究员(ResearchAssociate)
2013.1－2013.12美国杰克逊实验室研究科学家(ResearchScientist)
2013至今华中农业大学"青年千人"学者，湖北省"楚天学者"特聘教授
2013.12－2014.6华中农业大学生命科学技术学院特聘教授，博导
2014.7至今华中农业大学信息学院生物信息系系主任，特聘教授，博导
科研成果本课题组长期招聘各级研究人员，包括科研助理、博士生、博士后、副研究员、研究员。有从事教学工作意向的人员，也可以和我联系。
期刊论文 1. Guoliang Li,Liuyang Cai, Huidan Chang, Ping Hong, Qiangwei Zhou, Ekaterina V Kukakova,Nikolay A Kolchanov and Yijun Ruan. Chromatin Interaction Analysis withPaired-End Tag (ChIA-PET) sequencing technology and application. BMC Genomics，2014, S12, S11
2. 彭城#，李国亮#，张红雨，阮一骏(2014).染色质三维结构重建及其生物学意义，《中国科学：生命科学》，794-802.
3. Maejima, T., Inoue, T., Kanki, Y., Kohro, T., Guoliang Li, Ohta, Y., Kimura, H.,Kobayashi, M., Taguchi, A., Tsutsumi, S., et al. (2014). Direct Evidence forPitavastatin Induced Chromatin Structure Change in the KLF4 Gene in EndothelialCells. PLoS ONE, 9, e96005
4. Liang Niu, GuoliangLi, Shili Lin (2014), Statistical Models for Detecting DifferentialChromatin Interactions Mediated by a Protein, PLoS One, 9, e97560
5. 李国亮，阮一骏，谷瑞升，杜生明，起航三维基因组学研究，《科学通报》，2014, 59, 1165-1172
6. T. Inoue, T. Kohro, T. Tanaka, Y. Kanki, Guoliang Li, H. M. Poh, I. Mimura, M.Kobayashi, A. Taguchi, T. Maejima, J. I. Suehiro, A. Sugiyama, K. Kaneki, H.Aruga, S. Dong, J. F. Stevens, S. Yamamoto, S. Tsutsumi, T. Fujita, X. Ruan, H.Aburatani, M. Nangaku, Y. Ruan, T. Kodama, and Y. Wada, Cross-enhancement ofANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of theconformational proximity of two response elements, Genome Biology,vol. 15, p. R63, Apr 10 2014.
7. Dijun Chen, Liang-Yu Fu, Zhao Zhang, Guoliang Li, Hang Zhang, Li Jiang,Andrew P. Harrison, Hugh P. Shanahan, Christian Klukas, Hong-Yu Zhang, YijunRuan, Ling-ling Chen and Ming Chen, Dissecting the chromatin interactome of microRNAgenes, Nucleic Acids Research, 42, pp. 3028-3043, 2014
8. Kyong-Rim Kieffer Kwon, Zhonghui Tang, EwyMathe, Jason Qian, Myong-Hee Sung, GuoliangLi, Wolfgang Resch, Songjoon Baek, Nathanael Pruett, Lars Grontvend, LauraVian, Steevenson Nelson, Hossein Zare, Ofir Hakim, Deepak Reyon, Arito Yamane,Hirotaka Nakahashi, Alexander L. Kovalchuk, Jizhong Zou, J. Keith Joung,Vittorio Sartorelli, Chia-Lin Wei, Xiaoan Ruan, Gordon L. Hager, Yijun Ruan,Rafael Casellas, Interactome maps of mouse gene regulatory domains reveal basicprinciples of transcriptional regulation, Cell, 155, 1507-1520, 2013
9. Yubo Zhang, Chee-Hong Wong, Ramon Y. Birnbaum, Guoliang Li, Rebecca Favaro, Chew YeeNgan, Joanne Lim, Eunice Tai, Huay Mei Poh, Eleanor Wong, Fabianus HendriyanMulawadi, Ken Sung, Silvia Nicolis, Nadav Ahituv, Yijun Ruan and Chia-Lin Wei, Chromatinconnectivity maps reveal dynamic promoter-enhancer long-range associations, Nature,vol. 504, pp. 306-310, 2013
10. T.R. Mercer, S. L. Edwards, M. B. Clark, S. J. Neph, H. Wang, A. B. Stergachis,S. John, R. Sandstrom, Guoliang Li,K. S. Sandhu, Y. Ruan, L. K. Nielsen, J. S. Mattick, and J. A.Stamatoyannopoulos, DNase I-hypersensitive exons colocalize with promoters anddistal regulatory elements, Nature Genetics, vol. 45, pp. 852-859,2013
11. ZhizhuoZhang, Guoliang Li, Kim-Chuan Tohand Wing-Kin Sung, 3D Chromosome Modeling with Semi-definite Programming andHi-C Data, Journal of Computational Biology, 20, 831-846, 2013
12. ArkasubhraGhosh, Gaye Saginc, Shi Chi Leow, Eun Myong Shin, Marc Wong, Ting Dong Yan,Zhizhuo Zhang, Guoliang Li, Wing-KinSung, Jianbiao Zhou, Wee Joo Chng, Shang Li, Edison Liu, Vinay Tergaonkar, Telomerasedirectly regulates NFκB dependent transcription, Nature Cell Biology, 14(12)(Dec 2012): 1270-1281
13. ArgyrisPapantonis, Takahide Kohro, Sabyasachi Baboo, Joshua D Larkin, Binwei Deng,Shuichi Tsutsumi, Stephen Taylor, Mika Kobayashi, Guoliang Li, Huay Mei Poh, Xiaoan Ruan, Hiroyuki Aburatani, YijunRuan, Tatsuhiko Kodama, Youichiro Wada, Peter Richard Cook, TNFa signalsthrough specialized factories where responsive coding and miRNA genes aretranscribed, EMBO Journal, 31, 23 (Nov 28 2012), 4404-4414
14. KuljeetS. Sandhu, Guoliang Li, Huay MeiPoh, Yu Ling Kelly Quek, Yee Yen Sia, Su Qin Peh, Fabianus H Mulawadi, JingyaoZhang, Joanne Lim, Mile Sikic, Francesca Menghi, Anbupalam Thalamuthu, Wing KinSung, Xiaoan Ruan, Melissa J Fullwood, Edison Liu, Peter Csermely, Yijun Ruan,Large scale functional organization of long-range chromatin interactionnetworks, Cell Reports, 2, 5 (Nov 29 2012), 1207-1219
15. JingyaoZhang, Huay Mei Poh, Su Qin Peh, Yee Yen Sia, Guoliang Li, Fabianus Hendriyan Mulawadi, Yufen Goh, Melissa J.Fullwood, Wing-Kin Sung, Xiaoan Ruan, Yijun Ruan, ChIA-PET Analysis ofTranscriptional Chromatin Interactions, Methods (2012), 58, 3 (Nov 2012),289-299, doi: http://dx.doi.org/10.1016/j.ymeth.2012.08.009
16. FeiYao, Pramila N. Ariyaratne, Axel M. Hillmer, Wah Heng Lee, Guoliang Li, Audrey S. M. Teo, Xing Yi Woo, Zhenshui Zhang, JieqiP. Chen, Wan Ting Poh, Kelson F. B. Zawack, Chee Seng Chan, See Ting Leong, SayChuan Neo, Poh Sum D. Choi, Song Gao, Niranjan Nagarajan, Hervé Thoreau, AtifShahab, Xiaoan Ruan, Valère Cacheux-Rataboul, Chia-Lin Wei, Guillaume Bourque,Wing-Kin Sung, Edison T. Liu, Yijun Ruan, Long Span DNA Paired-End-Tag(DNA-PET) Sequencing Strategy for the Interrogation of Genomic StructuralMutations and Fusion-Point-Guided Reconstruction of Amplicons, PLOSONE 7 (9), e46152
17. TheENCODE Project Consortium (including GuoliangLi). 2012. An integrated encyclopedia of DNA elements in the human genome. Nature 489(7414): 57-74.
18. Jing-QuanLim, Chandana Tennakoon, Guoliang Li,Eleanor Wong, Yijun Ruan, Chia-Lin Wei and Wing-Kin Sung, BatMeth: ImprovedMapper for Bisulfite Sequencing Reads on DNA Methylation, Genome Biology, 13:R82 (3October 2012), 2012
19. Guoliang Li*, Xiaoan Ruan*, Raymond K.Auerbach*, Kuljeet Singh Sandhu*, Meizhen Zheng, Ping Wang, Huay Mei Poh, YufenGoh, Joanne Lim, Jingyao Zhang, Hui Shan Sim, Su Qin Peh, Fabianus HendriyanMulawadi, Chin Thing Ong, Yuriy L. Orlov, Shuzhen Hong, Zhizhuo Zhang, SteveLandt, Debasish Raha, Ghia Euskirchen, Chia-Lin Wei, Weihong Ge, Huaien Wang,Carrie Davis, Katherine I. Fisher-Aylor, Ali Mortazavi, Mark Gerstein, ThomasGingeras, Barbara Wold, Yi Sun, Melissa J. Fullwood, Edwin Cheung, Edison Liu,Wing-Kin Sung, Michael Snyder, and Yijun Ruan, Extensive Promoter-centeredChromatin Interactions Provide a Topological Basis for Transcription Regulation, Cell,148, 84-98 (* These authors contributed equally)
20. MelissaJ. Fullwood, Joanne Lee, Lifang Lin, GuoliangLi, Mikael Huss, Patrick Ng, Wing-Kin Sung, Shirish Shenolikar, Next-GenerationSequencing of Apoptotic DNA Breakpoints Reveals Association with ActivelyTranscribed Genes and Gene Translocations, PLoS ONE, 6, e26054, 2011
21. SayLi Kong*, Guoliang Li*, Siang Lin Loh, Wing-Kin Sung, Edison T. Liu, Cellularreprogramming by the conjoint action of ERα, FOXA1 and GATA3 for ligandinducible growth. Molecular Systems Biology 2011, 7:526(* These authors contributed equally)
22. LusyHandoko*, Han Xu*, Guoliang Li*,Chew Yee Ngan, Elaine Chew, Marie Schnapp, Charlie Wah Heng Lee, Chaopeng Ye,Joanne Lim Hui Ping, Fabianus Mulawadi, Eleanor Wong, Jianpeng Sheng, YuboZhang, Thompson Poh, Chee Seng Chan, Galih Kunarso, Atif Shahab, GuillaumeBourque, Valere Cacheux-Ratabou, Wing-Kin Sung, Yijun Ruan, Chia-Lin Wei, CTCF-MediatedFunctional Chromatin Interactome in Pluripotent Cells, Nature Genetics 43,630-638. (* These authors contributed equally)
23. KuljeetSingh Sandhu, Guoliang Li, Wing-KinSung, Yijun Ruan, Chromatin Interaction Networks and Higher Order Architecturesof Eukaryotic Genomes, Journal of Cellular Biochemistry 2011,112(9):2218-2221
24. HillmerAM, Yao F, Inaki K, Lee WH, Ariyaratne PN, Teo AS, Woo XY, Zhang Z, Zhao H,Ukil L, Chen JP, Zhu F, So JB, Salto-Tellez M, Poh WT, Zawack KF, Nagarajan N,Gao S, Guoliang Li, Kumar V, Lim HP,Sia YY, Chan CS, Leong ST, Neo SC, Choi PS, Thoreau H, Tan PB, Shahab A, RuanX, Bergh J, Hall P, Cacheux-Rataboul V, Wei CL, Yeoh KG, Sung WK, Bourque G,Liu ET, Ruan Y. 2011. Comprehensive long-span paired-end-tag mapping revealscharacteristic patterns of structural variations in epithelial cancer genomes. GenomeResearch 21:665-675.
25. Li Yuqing,Li Yi, Wedren S, Guoliang Li, CharnTH, Vasant DK, Bonnard C, Czene K, Humphreys K, Darabi H, Einarsdttir K et al:Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic inaugmenting the risk of estrogen receptor positive breast cancer. BreastCancer Research 2011, 13(1):R10.
26. JosephR, Orlov YL, Huss M, Sun W, Kong SL, Ukil L, Pan YF, Guoliang Li, Lim M, Thomsen JS et al: Integrative model of genomicfactors for determining binding site selection by estrogen receptor a. MolecularSystems Biology 2010, 6:456.
27. Guoliang Li*, M.J. Fullwood*, H. Xu*,F.H. Mulawadi, S. Velkov, V. Vega, P.N. Ariyaratne, Y.B. Mohamed, H.-S. Ooi, C.Tennakoon, C.-L. Wei, Y. Ruan, W.-K. Sung, ChIA-PET tool for comprehensivechromatin interaction analysis with paired-end tag sequencing, GenomeBiology 11 (2) (2010) R22, DOI: 10.1186/gb-2010-1111-1182-r1122 (* Theseauthors contributed equally to the work).
28. LouiseLaurent, Eleanor Wong, Guoliang Li,T. Huynh, A. Tsirigos, C.T. Ong, H.M. Low, W.-K. Sung, I. Rigoutsos, J. Loring,C.-L. Wei, Dynamic changes in the human methylome during differentiation, GenomeResearch 20 (3) (2010) 320-331.
29. Guoliang Li, Jian Ma, Louxin Zhang,Greedy Selection of Species for Ancestral State Reconstruction on Phylogenies:Elimination Is Better than Insertion, PLoS ONE 5 (2) (2010) e8985.doi:8910.1371/journal.pone.**.
30. Zhang,Louxin, Jian Shen, Jialiang Yang, GuoliangLi, Analyzing the Fitch Method for Reconstructing Ancestral States onUltrametric Phylogenetic Trees, Bulletin of Mathematical Biology (2010), 72, 1760-1782, DOI: 10.1007/s11538-11010-19505-11538.
31. Guoliang Li, Steel Mike, Louxin Zhang,More Taxa Are Not Necessarily Better For the Reconstruction of AncestralCharacter States, Systematic Biology 57 (4) (2008) 647-653.
32. AH.Morris, J. Orme,Jr., JD Truwit, J. Steingrub, C. Grissom, KH Lee, Guoliang Li, BT Thompson, R. Brower, M.Tidswell, G. Bernard, D. Sorenson, K. Sward, H. Zheng, D. Schoenfeld, H.Warner, A replicable method for blood glucose control in critically illpatients, Critical Care Medicine. 36(6):1787-1795, June 2008.
33. Guoliang Li, Tze-Yun Leong, and LouxinZhang, Translation Initiation Sites Prediction with Mixture Gaussian Models inHuman cDNA Sequences. IEEE Transactions on Knowledge and DataEngineering, 2005. 17(8): p. 1152-1160.
34. Guoliang Li and Tze-Yun Leong, FeatureSelection for the Prediction of Translation Initiation Sites. Genomics,Proteomics & Bioinformatics, 2005. 3(2): p. 73-83.
会议论文 35. ZhizhuoZhang, Guoliang Li, Kim-Chuan Tohand Wing-Kin Sung, Inference of Spatial Organizations of Chromosomes UsingSemi-definite Embedding Approach and Hi-C Data, Research in ComputationalMolecular Biology (RECOMB), Lecture Notes in Computer Science Volume 7821,2013, pp 317-332
36. Guoliang Li, Tze-Yun Leong, ActiveLearning for Causal Bayesian Network Structure with Non-symmetricalEntropy, PAKDD 2009, LNAI 5476,Springer-Verlag, 2009, pp. 290-301.
37. BinHan, Guoliang Li, Tze-Yun Leong,Yanchun Zhang, Lihua Li, Wei Liu, Lei Zhu, Weidong Xu, Identifying CausalEffects from Data for the Clinical Ventilation Process Modeling. Proceedings ofthe 2008 International Conference on BioMedical Engineering and Informatics.Sanya, Hainan, China, 517-521.
38. Guoliang Li, Tze-Yun Leong, BiomedicalKnowledge Discovery with Topological Constraints Modeling in Bayesian Networks:A Preliminary Report, in: World Congress on Health (Medical) Informatics(MedInfo) (IOS Press, Brisbane, Australia, 2007) 560-565.
39. Guoliang Li, Jian Ma, Louxin Zhang,Selecting Genomes for Reconstruction of Ancestral Genomes, in: Proceedings ofthe Fifth Annual RECOMB Satellite Workshop on Comparative Genomics (RECOMB-CG),LNBI 4751 (2007) 110-121.
40. QiongyuChen, Guoliang Li, Tze-Yun Leong, Chew-KiatHeng, Predicting Coronary Artery Disease with Medical Profile and GenePolymorphisms Data, in: World Congress on Health (Medical) Informatics(MedInfo) (IOS Press, Brisbane, Australia, 2007) 1219-1224.
41. RohitJoshi, Guoliang Li, Tze-Yun Leong,Context-aware Probabilistic Reasoning for Proactive Healthcare, IJCAI workshopof Artificial Intelligence Techniques for Ambient Intelligence, 2007
42. Guoliang Li and Tze-Yun Leong, Aframework to learn Bayesian Networks from changing, multiple-source biomedicaldata. in Proceedings of the 2005 AAAI Spring Symposium on Challenges toDecision Support in a Changing World. Stanford University, CA, USA, 66-72.
43. Guoliang Li, Tze-Yun Leong, LouxinZhang, Translation Initiation Sites Prediction with Mixture Gaussian Models,the Proceedings of the 4th Workshop on Algorithms in Bioinformatics (WABI2004), LNBI 3240, Bergen, Norway, 2004, pp. 338-349.
44. BinHan, Tze-Yun Leong, Guoliang Li,Learning the Dynamic Bayesian Networks Structure of Ventilation Process in aLinear System Identification Perspective, in: IEEE Workshop on Life ScienceData Mining (LSDM) (Brighton, UK, 2004)
专利 1. 谭民;景奉水;梁自泽;李国亮;王跃：开放式工业机器人控制平台，中国实用新型专利，专利公开号：CN**, 公开时间：2001.09.12
2. 谭民;梁自泽;李国亮;景奉水;王跃：开放式工业机器人视觉控制平台，中国实用新型专利，专利公开号：CN**, 公开时间：2002.09.11
3. 谭民;景奉水;梁自泽;李国亮;王跃：开放式工业机器人控制平台，中国发明专利，专利公开号： CN**, 公开时间：2002.04.17
4. 谭民;梁自泽;李国亮;景奉水：开放式工业机器人视觉控制平台，中国发明专利，专利公开号：CN**, 公开时间：2003.05.14
备注本课题组长期招聘各级研究人员，包括科研助理、博士生、博士后、副研究员、研究员。有从事教学工作意向的人员，也可以和我联系。
获奖经历
1999中国科学院优秀研究生奖学金
2001~2002新加坡-麻省理工学院学术联盟奖学金
2004/2005新加坡国立大学计算学院，院长奖学金
2005~2007新加坡国立大学计算学院，研究奖学金
2005/2006新加坡国立大学，校长奖学金
2006/2007新加坡国立大学，校长奖学金
2013入选中组部第四批“青年****”
2013入选湖北省“楚天学者”特聘教授
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