You can also call them via subprocess module, but...
For Python 2.7 and newer, simply use
subprocess.check_call(['open', filename])
In Python 3.5+ you can equivalently use the slightly more complex but also somewhat more versatile
subprocess.run(['open', filename], check=True)
If you need to be compatible all the way back to Python 2.4, you can use subprocess.call() and implement your own error checking:
try:
retcode = subprocess.call("open " + filename, shell=True)
if retcode < 0:
print >>sys.stderr, "Child was terminated by signal", -retcode
else:
print >>sys.stderr, "Child returned", retcode
except OSError, e:
print >>sys.stderr, "Execution failed:", e
Now, what are the advantages of using subprocess?
Security: In theory, this is more secure, but in fact we're needing to execute a command line one way or the other; in either environment, we need the environment and services to interpret, get paths, and so forth. In neither case are we executing arbitrary text, so it doesn't have an inherent "but you can type 'filename ; rm -rf /'" problem, and if the file name can be corrupted, using subprocess.call gives us little additional protection.
Error handling: It doesn't actually give us any more error detection, we're still depending on the retcode in either case; but the behavior to explicitly raise an exception in the case of an error will certainly help you notice if there is a failure (though in some scenarios, a traceback might not at all be more helpful than simply ignoring the error).
Spawns a (non-blocking) subprocess: We don't need to wait for the child process, since we're by problem statement starting a separate process.
To the objection "But subprocess is preferred." However, os.system() is not deprecated, and it's in some sense the simplest tool for this particular job. Conclusion: using os.system() is therefore also a correct answer.
A marked disadvantage is that the Windows start command requires you to pass in shell=True which negates most of the benefits of using subprocess.