单光子发射计算机断层成像原理,单光子发射计算机断层显像 (SPECT)

(SPECT)

SPECTSPECTSPECTSPECTSPECT

/

X

ECTSPECTPET

ECTEmission Computed tomography(CT)

ECTTCT (Transmission Computed Tomography)XCTTCTECT

ECTXCTXCTECTXCTECTECT

ECT

ECTECT

NaI

NaI

New Scintillators Developed RecentlyLSOPbWO4Discovered in ~1992.Approximately 10 years of R&D before large scale production.

[NaI(Tl)]3/830-50 cm

710610

PMT3194375616917127

(PMT)PMT(x,y)(x,y)

(SMC)

NaI(Tl)x, y

P2P1P3X1X2X30NaI(Tl)P1,P2,P3PMTPMTX1,X2,X3PMTXP=P1+P2+P3ZXX

Scintillation Camera

SPECT SPECT ECG

Charlie Steinbeck522012GeorgiaSteinbeck

per-fusionventilation

SteinbeckSteinbeck

Tc-MAA (Tc-MAA

SteinbeckSteinbeck

SPECTSingle Photon Emission Computed Tomography

SiemensSPECT

GESPECT

SPECT

SPECT

SPECT

SPECT1959 David Kuhl Roy Edwards1963 Kuhl EdwardsSPECT1976 KeyesSPECT1983 SPECT2003 SPECT

SPECT SPECTTC-99m TI-201 SPECT

SPECT

SPECT36036FBP

SPECT

SPECTXCTXCTX()SPECT

SPECTTc-99mTc-99m

SPECT

(FBP)FBPSPECTFBP FBP

SPECT60511keV( map)

Tc-99m

MAA1%

SPECT MIBI MDP ECD

Tc-99m 6.02141keVX1/10~1/2Tl-201I-131I-123Ga-67In-111

SPECT

SPECT

6~12mm

SPECTCTCT

SPECT

RR-R2475/0.833300~400

SPECT-

SPECT-

SPECT-

SPECT- 2SPECT:(A)(B) SPECT

SPECT-

SPECTSPECTSPECTSPECTSPECT18F-FDG/PET

TermsECT: Emission Computed TomographySPECT: Single Photon Emission Computed TomographyPET: Positron Emission TomographyFBP: Filtered Backprojection MIBI: Methoxyisobutyl Isonitrile MDP: Methylenediphosphonate ECD: Ethylcysteinate Dimer

TermsPMT: photomultiplier tube SMC: summing matrix circuit ECG: ElectrocardiographGFR: glomerular filtration rate ERPF: Effective renal plasma flow