signature=7fb99e8bead6214be0eb5e2c3ced83fe,Release behaviors and kinetics of coated bead﹐n﹕tring nan...

摘要：

The bead﹐n﹕tring with special beads in micro level could act as an effective carrier for solid drug particles as well as obtain continuous and sustained release profile. Tetracycline hydrochloride (TCH), used as solid model drug particles, was grounded to obtain nanoscale and wellヾistributed size. Electrospun Poly (lacticヽoゞlycolic acid) (PLGA) bead﹐n﹕tring nanofibers loaded with TCH of different particle sizes were fabricated for controlled drug delivery. The morphology of TCH particles and bead﹐n﹕tring nanofiber were observed by particle sizer and scanning electron microscopy (SEM). The effects of drug particle size on the release behaviors of nanofibers were further investigated and analyzed by a UV￢isible light spectrophotometer. In vitro release results suggested that bead﹐n﹕tring nanofibers encapsulated with grounded TCH particles had higher total drug release quantity compared with unground particles loaded nanofibers. Coating on the surface of PLGA/TCH nanofibers to investigated the controlled‐release effects and the release mechanism to understand the drug﹑rometric carriers' interaction. The results indicated that coating on both sides of nanofibrous membranes could effectively decrease the initial burst release. Bead﹐n﹕tring nanofibers proved to be promising mats for drug delivery applications. This article is protected by copyright. All rights reserved.

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