signature=793909a369a10e580d91a624768d6e3f,FRI0003 Determination of interferon (IFN) signatures for ...

摘要：

Clustering was done separately for 5 gene sets, denoted B-30, P-11, M-20, G-7, and O-3. Two of the gene sets (M-20 and G-7) were 95% and 100% matched to sets used in clinical trials of IFN-inhibiting treatments. Consistent with previous reports, all of the gene sets assigned about 40-50% of visits (96 to 118 patient-visits) to an "IFN high" group characterized by IFN pathway expression that was higher than healthy volunteers. In a cross-sectional analysis using the P-11 gene set, membership in the IFN high group was associated with higher SLEDAI score than IFN low assignment (9.73 vs. 7.70, p<0.0001) and higher TNFSF13B (BLYS/BAFF) gene expression (2.4 fold increase, p=0.0005). Most of the patients followed longitudinally remained in the same group over the course of the study, despite changes of gene expression with disease improvement and flare. IFN group assignments were similar for the B-30 and P-11 gene sets, and also similar among the M-20, G-7, and O-3 gene sets, but differed more across these groups. For instance, 21 patient-visits (9%) were assigned to the IFN high group by the G-7 gene set, but placed in the IFN low group by the P-11 gene set.

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