# 187. Repeated DNA Sequences

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All DNA is composed of a series of nucleotides abbreviated as A, C, G, and T, for example: "ACGAATTCCG". When studying DNA, it is sometimes useful to identify repeated sequences within the DNA.

Write a function to find all the 10-letter-long sequences (substrings) that occur more than once in a DNA molecule.

For example,

Given s = "AAAAACCCCCAAAAACCCCCCAAAAAGGGTTT",

Return:
["AAAAACCCCC", "CCCCCAAAAA"].


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1.我的答案

class Solution {
public:
vector<string> findRepeatedDnaSequences(string s) {
vector<string> vec;
if(s.size() < 10)
return vec;
map<string,int>mp;
for(int i = 0; i <= s.size()-10; i++){
string str = s.substr(i,10);
if(mp.find(str) == mp.end())
mp[str] = 1;
else{
mp[str]++;
if(mp[str] == 2)
vec.push_back(str);
}
}
return vec;
}
};

2.别人的答案 8ms

1048576=4^10

hashmap用char来计数 0~256（因此这里有隐患，若相同字符串的次数大于256次呢？）

vector<string> findRepeatedDnaSequences(string s) {
char  hashMap[1048576] = {0};
vector<string> ans;
int len = s.size(),hashNum = 0;
if (len < 11) return ans;
for (int i = 0;i < 9;++i)
hashNum = hashNum << 2 | (s[i] - 'A' + 1) % 5;
for (int i = 9;i < len;++i)
if (hashMap[hashNum = (hashNum << 2 | (s[i] - 'A' + 1) % 5) & 0xfffff]++ == 1)
ans.push_back(s.substr(i-9,10));
return ans;
}

a simple solution is only allowing hashMap to has three status, 0 for none, 1 for 1, 3 for multiple.

vector<string> findRepeatedDnaSequences(string s) {
char flag[262144] ={0};
vector<string> result;
int len,DNA=0,i;
if((len=s.length())< 11) return result;
for(i = 0 ; i < 9; i++)
DNA = DNA << 2| (s[i] - 'A' + 1) % 5;
for(i = 9;i<len;i++)
{
DNA = (DNA<<2 & 0xFFFFF)|(s[i] - 'A' + 1)%5;
if(!(flag[DNA>>2]&(1<<((DNA&3) << 1))))
flag[DNA>>2] |= (1<<((DNA&3) << 1));
else if(!(flag[DNA>>2]&(2<<((DNA&3) << 1))))
{
result.push_back(s.substr(i-9,10));
flag[DNA>>2] |= (2<<((DNA&3) << 1));
}
}
return result;
}

3.另一个大神的答案

The main idea is to store the substring as int in map to bypass the memory limits.

There are only four possible character A, C, G, and T, but I want to use 3 bits per letter instead of 2.

Why? It's easier to code.

A is 0x41, C is 0x43, G is 0x47, T is 0x54. Still don't see it? Let me write it in octal.

A is 0101, C is 0103, G is 0107, T is 0124. The last digit in octal are different for all four letters. That's all we need!

We can simply use s[i] & 7 to get the last digit which are just the last 3 bits, it's much easier than lookup table or switch or a bunch of if and else, right?

We don't really need to generate the substring from the int. While counting the number of occurrences, we can push the substring into result as soon as the count becomes 2, so there won't be any duplicates in the result.

vector<string> findRepeatedDnaSequences(string s) {
unordered_map<int, int> m;
vector<string> r;
int t = 0, i = 0, ss = s.size();
while (i < 9)
t = t << 3 | s[i++] & 7;
while (i < ss)
if (m[t = t << 3 & 0x3FFFFFFF | s[i++] & 7]++ == 1)
r.push_back(s.substr(i - 10, 10));
return r;
}

Update:

I realised that I can use s[i] >> 1 & 3 to get 2 bits, but then I won't be able to remove the first loop as 1337c0d3r suggested.

4.对3中的代码进行精简

Another observation is the mapped value need not be an integer counter, and could simply be a boolean to further save space. This requires some extra logic though:

vector<string> findRepeatedDnaSequences(string s) {
unordered_map<int, bool> m;
vector<string> r;
for (int t = 0, i = 0; i < s.size(); i++) {
t = t << 3 & 0x3FFFFFFF | s[i] & 7;
if (m.find(t) != m.end()) {
if (m[t]) {
r.push_back(s.substr(i - 9, 10));
m[t] = false;
}
} else {
m[t] = true;
}
}
return r;
}

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