将series的values直接转换为numpy的整型即可。
datetime ts date
0 2016-01-01 00:00:01 1451602801 2016-01-01
1 2016-01-01 01:00:01 1451606401 2016-01-01
2 2016-01-01 02:00:01 1451610001 2016-01-01
3 2016-01-01 03:00:01 1451613601 2016-01-01
4 2016-01-01 04:00:01 1451617201 2016-01-01
df['ts'] = df.datetime.values.astype(np.int64) // 10 ** 9
print (df)
datetime ts
0 2016-01-01 00:00:01 1451606401
1 2016-01-01 01:00:01 1451610001
2 2016-01-01 02:00:01 1451613601
3 2016-01-01 03:00:01 1451617201
4 2016-01-01 04:00:01 1451620801
5 2016-01-01 05:00:01 1451624401
6 2016-01-01 06:00:01 1451628001
7 2016-01-01 07:00:01 1451631601
8 2016-01-01 08:00:01 1451635201
9 2016-01-01 09:00:01 1451638801
10 2016-01-01 10:00:01 1451642401
11 2016-01-01 11:00:01 1451646001
12 2016-01-01 12:00:01 1451649601
13 2016-01-01 13:00:01 1451653201
14 2016-01-01 14:00:01 1451656801
15 2016-01-01 15:00:01 1451660401
16 2016-01-01 16:00:01 1451664001
17 2016-01-01 17:00:01 1451667601
18 2016-01-01 18:00:01 1451671201
19 2016-01-01 19:00:01 1451674801
20 2016-01-01 20:00:01 1451678401
21 2016-01-01 21:00:01 1451682001
22 2016-01-01 22:00:01 1451685601
23 2016-01-01 23:00:01 1451689201
24 2016-01-02 00:00:01 1451692801