by the analogy of finding a needle in a haystack 类似大海捞针
from scratch 从头开始
is further exacerbated 进一步加剧/恶化
to this end 为此(放句首)
in view of 鉴于
are essentially tied(for ....) (在xxx方面)差不多
the advent of xx xx的到来
a means of doing xx 做某事的一种方法
vice versa 反之亦然 (放句尾,xxxxx and vice versa)
incorporate A in B 把A融入B中
As such, ... 因此,......
On top of this,...... 基于此,......
De novo 从头 比如 De novo molecule generation