4ARM-PEG-Silane 四臂PEG硅烷

4ARM-PEG-Silane  四臂PEG硅烷

基本信息：

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中文名称：四臂聚乙二醇硅烷(4ARM-PEG-Silane)

中文别名：四臂PEG硅烷

英文名称：4ARM-PEG-Silane

CAS：-

分子量：2000,5000，10000,20000

纯度：95%以上

应用简介：

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silanePEG (PEG-Si) is a surface reactive PEG derivative that can be used to modifyglass, silica and other surfaces via the reaction between hydroxyl group andethoxyl/methoxyl silane. Pegylation can greatly suppress the non-specificbinding of charged molecules to the modified surfaces. And they have wideapplications for medica device, biomems or biocompatible material development.

ReactionProcedures:

Generally,silane PEG is first dissolved in a mixture of ethanol/water solution, thenallow the solution to contact with oxidized glass or silica surface for 30 minto 2 hours. Under this condition, silane PEG should bind to the materialcovalently.

MaterialsRequired:

Pegylationsolution: Ethanol/water (w/w, 95%/5%);

SilanePEG stock solution, 10~50 mg/mL in pegylation solution, prepare in fresh.

Washingsolution: Distilled water.

ReactionSteps:

1.Dissolve targeted materials in Pegylation buffer.

2. Addsilane PEG stock solution to the targeted conjugation materials with the finalconcentration keep at least 10 mg/mL. 10~50 molar excess of silane PEG neededfor optimal conjugation;

3.Allow mixture agitates at room temperature for 30 min at room temperature or 2hours at 4 -20℃.

4. Washout unreacted materials either by distilled water.

物理性质：

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状态：液体或者固体。

溶解性：溶于DMSO,DMF,DCM，溶于水。

保持条件：-20℃长期保存，避光，干燥。

注意事项：取用一定要干燥，避免频繁的溶解和冻干。

技术指标：

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纯度（PEG）：95%以上

取代率（Silane）：95%以上

分散系数（PDI）：小于等于1.05

分析：COA、GPC、NMR、MALDI-TOF