nginx: [error] invalid PID number "" in "/usr/local/nginx/logs/nginx.pid"解决

部署flask项目，添加配置文件后，想重启一下nginx，结果报错：

$ sudo nginx -s reload
nginx: [error] invalid PID number "" in "/usr/local/nginx/logs/nginx.pid"

原因分析：
nginx.pid丢掉了
解决：

issued a nginx -s stop and after that I got this error when trying to reload it.
[error]: invalid PID number “” in “/var/run/nginx.pid”
That /var/run/nginx/pid file is empty atm.
What do I need to do to fix it?
nginx -s reload is only used to tell a running nginx process to reload its config. After a stop, you don't have a running nginx process to send a signal to. Just run nginx (possibly with a -c /path/to/config/file)

运行命令，问题得以解决：

sudo /usr/sbin/nginx -c /etc/nginx/nginx.conf

$ sudo /usr/sbin/nginx -c /etc/nginx/nginx.conf
nginx: [emerg] bind() to 0.0.0.0:8000 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:80 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:8090 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:2021 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:8000 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:80 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:8090 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:2021 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:8000 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:80 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:8090 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:2021 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:8000 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:80 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:8090 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:2021 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:8000 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:80 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:8090 failed (98: Address already in use)
nginx: [emerg] bind() to 0.0.0.0:2021 failed (98: Address already in use)
nginx: [emerg] still could not bind()
$ sudo /usr/sbin/nginx -s reload
$ ps -ef | grep nginx
root     23072     1  0 14:47 ?        00:00:00 nginx: master process /usr/sbin/nginx -c /etc/nginx/nginx.conf
root     24923 23072  0 14:50 ?        00:00:00 nginx: worker process                   
root     24924 23072  0 14:50 ?        00:00:00 nginx: worker process                   
root     24925 23072  0 14:50 ?        00:00:00 nginx: worker process                   
root     24926 23072  0 14:50 ?        00:00:00 nginx: worker process                   
root     24927 23072  0 14:50 ?        00:00:00 nginx: worker process                   
root     24928 23072  0 14:50 ?        00:00:00 nginx: worker process                   
606      25538  4063  0 14:50 pts/8    00:00:00 grep nginx

参考：https://www.jb51.net/article/45658.htm