DOTA-c(RGDyK)，促进细胞特异性摄取，以环状结构形式存在

英文名：DOTA-cyclo(RGDyK)，DOTA-c(RGDyK)

DOTA-cyclo(Arg-Gly-Asp-DTyr-Lys)

一、Product parameters：

1.Molecular formula：C43H67N13O15

2.Molecular weight：1005.49

3.Packaging specification：1g、5g、10g, flexible packaging, including 100mg packaging and 500mg 1g and 5g large packaging

Product structure：

 

二、Reaction characteristics：

DOTA-cyclo(Arg-Gly-Asp-DTyr-Lys)，简称DOTA-RGD，是一种常用的肿瘤靶向分子。它以环状结构形式存在，其中Arg-Gly-Asp（RGD）序列是识别肿瘤血管的主要识别基序。

在DOTA-RGD中，DOTA（1,4,7,10-四氮杂环十二烷）是一种常用的金属螯合剂，可以与放射性元素如Tc、Re等螯合，实现肿瘤的显像和治疗。RGD序列则可以与肿瘤血管内皮细胞表面的αvβ3整合素受体特异性结合，从而实现肿瘤的靶向定位。

（上述信息均由陕西新研博美生物科技有限公司的小编木木所整理）

三、Matters for use：

It is sensitive to light and temperature. In order to use the reagent effectively, the material should always be kept in a low temperature dry condition, away from light, and avoid frequent thawing and freezing.

四、storage conditions:

Store at - 20 ℃ as much as possible. If conditions permit, the material can be treated under inert gas to obtain better stability of the reagent.

 

【Reagent related products】

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p-NO2-Bn-DOTA

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p-SCN-Bn-DTPA

p-SCN-Bn-HEHA

p-SCN-Bn-NOTA

DOTA-PEG4-MeTz

DOTA-DBCO

DOTA-cyclo(RGDyK)

DOTA-E[c(RGDfK)2]

DOTA-cyclo(RGDfK)