https://github.com/satazor/js-spark-md5
document.getElementById('file').addEventListener('change', function () { var blobSlice = File.prototype.slice || File.prototype.mozSlice || File.prototype.webkitSlice, file = this.files[0], chunkSize = 2097152, // Read in chunks of 2MB chunks = Math.ceil(file.size / chunkSize), currentChunk = 0, spark = new SparkMD5.ArrayBuffer(), fileReader = new FileReader(); fileReader.onload = function (e) { console.log('read chunk nr', currentChunk + 1, 'of', chunks); spark.append(e.target.result); // Append array buffer currentChunk++; if (currentChunk < chunks) { loadNext(); } else { console.log('finished loading'); console.info('computed hash', spark.end()); // Compute hash } }; fileReader.onerror = function () { console.warn('oops, something went wrong.'); }; function loadNext() { var start = currentChunk * chunkSize, end = ((start + chunkSize) >= file.size) ? file.size : start + chunkSize; fileReader.readAsArrayBuffer(blobSlice.call(file, start, end)); } loadNext(); });