avoid Sys.WebForms.PageRequestManagerTimeOutException while using Ajax

set the ScripManager property as AsyncPostBackTimeout="36000"

or

you can catch the exception by using this

<script type="text/javascript">

function onEndRequest(sender, e)
{
var err = e.get_error();

if (err != null && err.name === 'Sys.WebForms.PageRequestManagerTimeoutException')
{
e.set_errorHandled(true);
}
}

Sys.WebForms.PageRequestManager.instance.add_endRe quest(onEndRequest);

</script>