GPS-SNO 1.0 是一个用于预测蛋白质亚硝基化修饰位点的计算软件。基于手动收集的实验验证数据，通过改进的GPS 3.0算法进行预测，该工具在留一交叉验证中表现出良好的性能，准确率为75.70%，敏感性为55.32%，特异性为80.11%。GPS-SNO 1.0 的在线服务和本地包可供免费使用，为实验验证提供了潜在的预测结果。
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GPS-SNO: Computational prediction of protein S -nitrosylation sites with a modified GPS algorithm. Yu Xue , Zexian Liu, Xinjiao Gao, Changjiang Jin, Longping Wen, Xuebiao Yao, and Jian Ren . Plos One . 2010;5(6):e11290 [Full Text] [PDF] |
The 1998 Nobel Prize in Physiology or Medicine was awarded for seminal discoveries that nitric oxide (NO) is a freely-diffusible signalling molecule and second messenger, regulates the production of cyclic GMP (cGMP), and plays essential roles in the cardiovascular system. Later, flood of studies challenged this fundamental view by observing that NO could spatially and temporally target specific cysteine thiols and transition metals of proteins, a reversibly post-translational modification (PTM) termed as
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