System.IO.FileInfo file = new System.IO.FileInfo(MyFileName);
Response.Clear();
Response.AddHeader("Content-Disposition", "attachment; filename=" + HttpUtility.UrlEncode(file.Name));
Response.AddHeader("Content-Length", file.Length.ToString());
Response.ContentType = "application/octet-stream";
Response.WriteFile(file.FullName);
Response.End();