java.io.EOFException: Unexpected EOF read on the socket；CannotGetJdbcConnectionException

生产环境有一段时间没改动什么，突然某天很多用户使用时，页面地方很多超时，直接重启系统解决，系统是部署在阿里云上的。
java.io.EOFException: Unexpected EOF read on the socket;
The error occurred while executing a query
Cause: org.springframework.jdbc.CannotGetJdbcConnectionException: Failed to obtain JDBC Connection; nested exception is java.sql.SQLTransientConnectionException: DatebookHikariCP - Connection is not available, request timed out after 30000ms.