NMN研发背景与文献参考

NMN分子结构 NMN词典

中文名称：beta-烟酰胺单核苷酸

中文别名：β-烟酰胺单核苷酸; 烟酰胺核苷酸

英文名称：beta-nicotinamide mononucleotide

英文别名：

3-carbamoyl-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridinium;

3-(Aminocarbonyl)-1-(5-O-phosphonato-beta-D-ribofuranosyl)pyridinium;

3-(aminocarbonyl)-1-(5-O-phosphono-beta-D-ribofuranosyl) ;

3-carbamoyl-1-(5-O-phosphonopentofuranosyl)pyridinium; coenzyme NMN;

β-Nicotinamide mononucleotide; Nicotinamide mononucleotide; NMN; inner salt; Pyridinium;

CAS号：1094-61-7

EINECS号：214-136-5

分子式：C11H15N2O8P

分子量：334.2192

InChI：InChI=1/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1

性质描述：其外观呈冷冻干燥粉末状，溶于水。

NMN是NAD+的前体 NAD+又叫辅酶Ⅰ，全称烟酰胺腺嘌呤二核苷酸，又称二磷酸烟苷，存在每一个细胞中参与上千项反应。NAD+是三羧酸循环的重要辅酶，促进糖、脂肪、氨基酸的代谢，参与能量的合成；NAD+又是辅酶I消耗酶的唯一底物（DNA修复酶PARP的唯一底物、长寿蛋白Sirtuins的唯一底物、环ADP核糖合成酶CD38/157的唯一底物）。

引用文献

1，NAD+ in aging, metaboli ** , and neurodegeneration‍

2，Loss of NAD Homeostasis Leads to Progressive and ReversibleDegeneration of Skeletal Muscle

3，Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice‍

4，CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechani **

5，Nicotinic acid, nicotinamide, and nicotinamideriboside: amolecular evaluation of NAD+ precursor vitamins in hu ** n nutrition.Bogan KL,Brenner C Annu Rev Nutr. 2008; 28():115-30.

6，Resistance Exercise Training Alters Mitochondrial Function in Hu ** nSkeletal Muscle‍

7，Pathways and subcellular compartmentation of NADbiosynthesis in hu ** n cells: from entry of extracellular precursors tomitochondrial NAD generation.‍

8，Loss of NAD Homeostasis Leads to Progressive andReversible Degeneration of Skeletal Muscle (Fredrick 2016)

9，Digestion andabsorption of NAD by the s ** ll intestine of the rat (Henderson, 1983)

10, Effects of a widerange of ** tary nicotinamide riboside (NR) concentrations on metabolicflexibility and white adipose tissue (WAT) of mice fed a mildly obesogenic ** t

11，Nicotinamide Mononucleotide, an NAD+ Precursor, Rescues Age-AssociatedSusceptibility to AKI in a Sirtuin 1-Dependent Manne‍

12‍，The NAD+ Precursor Nicotinamide Riboside Enhances OxidativeMetaboli ** and Protects against High-Fat Diet-Induced Obesity‍

13‍，Long-Term Administration of Nicotinamide Mononucleotide MitigatesAge-Associated Physiological Decline in Mice.Cell Metaboli ** , v.24, no.6, 2016Dec 13, p.795(12)‍

14，In vivo NAD assay reveals the intracellular NAD contents and redoxstate in healthy hu ** n brain and their age dependences. Zhu, X.H., Lu, M., Lee,B.Y., Ugurbil, K., and Chen, W. Proc. Natl. Acad. Sci. USA. 2015; 112:2876–2881

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16， Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes.Cantó, C., Sauve, A.A., and Bai, P. Mol. Aspects Med. 2013; 34: 1168–1201

17， New insights into the molecular and cellular functions ofpoly(ADP-ribose) and PARPs.

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18，Therapeutic applications of PARP inhibitors: anticancer therapy andbeyond. Curtin, N.J. and Szabo, C. Mol. Aspects Med. 2013; 34: 1217–1256

19， A conserved NAD+ binding pocket that regulates protein-proteininteractions during aging

20， Evolution and function of the ADP ribosyl cyclase/CD38 gene familyin physiology and pathology. Malavasi, F., Deaglio, S., Funaro, A., Ferrero,E., Horenstein, A.L., Ortolan, E., Vaisitti, T., and Aydin, S. Physiol. Rev.2008; 88: 841–886

21， Sirtuin 1-mediated effects of exercise and resveratrol onmitochondrial biogenesis. Menzies, K.J., Singh, K., Saleem, A., and Hood,D.A.J. Biol. Chem. 2013; 288: 6968–6979

22， SIRT1 metabolic actions: Integrating recent advances from mousemodels. Boutant, M. and Canto, C. Mol. Metab. 2014; 3: 5–18

23， Mitochondrial sirtuins and their relationships with metabolicdisease and cancer.

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24， Nicotinamide mononucleotide, a key NAD+ intermediate, treats thepathophysiology of ** t- and age-induced diabetes in mice

25， P7C3 neuroprotective chemicals block axonal degeneration andpreserve function after trau ** tic brain injury. Yin, T.C., Britt, J.K., DeJesús Cortés, H., Lu, Y., Genova, R.M., Khan, M.Z., Voorhees, J.R., Shao, J.,Katz ** n, A.C., Huntington, P.J. et al. Cell Rep. 2014; 8: 1731–1740

26， Neuroprotective efficacy of aminopropyl carbazoles in a mouse modelof Parkinson disease. De Jesús-Cortés, H., Xu, P., Drawbridge, J., Estill, S.J.,Huntington, P., Tran, S., Britt, J., Tesla, R., Morlock, L., Naidoo, J. et al.Proc. Natl. Acad. Sci. USA. 2012; 109: 17010–17015

27， Neuroprotective efficacy of aminopropyl carbazoles in a mouse modelof amyotrophic lateral sclerosis. Tesla, R., Wolf, H.P., Xu, P., Drawbridge,J., Estill, S.J., Huntington, P., McDaniel, L., Knobbe, W., Burket, A., Tran,S. et al. Proc. Natl. Acad. Sci. USA. 2012; 109: 17016–17021

28， NAD+ Replenishment Improves Lifespan and Healthspan in AtaxiaTelangiectasia Models via Mitophagy and DNA Repair Substance with the potentialto postpone aging

29， Neuronal SIRT1 activation as a novel mechani ** underlying theprevention of Alzheimer disease amyloid neuropathology by calorie restriction.Qin, W., Yang, T., Ho, L., Zhao, Z., Wang, J., Chen, L., Zhao, W.,Thiyagarajan, M., MacGrogan, D., Rodgers, J.T. et al. J. Biol. Chem. 2006; 281:21745–21754

30，Nicotinamide riboside restores cognition through an upregulation ofproliferator activated receptor-γ coactivator 1α regulated β secretase 1degradation and mitochondrial gene expression in Alzheimer’s mouse models.Gong, B., Pan, Y., Vempati, P., Zhao, W., Knable, L., Ho, L., Wang, J., Sastre,M., Ono, K., Sauve, A.A., and Pasinetti, G.M. Neurobiol. Aging. 2013; 34:1581–1588

31，NAD+ and sirtuins in aging and disease (I ** i, 2014)

32，Declining NAD+ Induces a Pseudohypoxic State DisruptingNuclear-Mitochondrial Communication during Aging (Gomes, Sinclair,2013)

33, un Li,Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn, David A. Sinclair.A conserved NAD+ binding pocket that regulates protein-protein interactions duringaging. Science 355：1312,(2017)

34，Mouchiroud L., Houtkooper R.H., Moullan N., et al.. TheNAD+/Sirtuin pathway modulates longevity through activation of mitochondrialUPR and FOXO signaling. Cell 154: 430-441 (2013)

35，Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats thePathophysiology of Diet- and Age-Induced Diabetes in Mice (Yoshino, 2011

36，Head to Head Comparison of Short-Term Treatment with the NAD(+)Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in ObeseFe ** le Mice (Uddin, 2016)

37， Evidence for a direct effect of the NAD+ precursor acipimox onmuscle mitochondrial function in hu ** ns. van de Weijer, T., Phielix, E., Bilet,L., Williams, E.G., Ropelle, E.R., Bierwagen, A., Livingstone, R., Nowotny, P.,Sparks, L.M., Paglialunga, S. et al. Diabetes. 2015; ** : 1193–1201

38，Nicotinamide mononucleotide attenuates brain injury afterintracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway (Wei, 2017)

39，Nicotinamide mononucleotide protects against β-amyloidoligomer-induced cognitive impairment and neuronal death (Wang, 2016)

40，Nicotinamide mononucleotide inhibits JNK activation to reverseAlzheimer disease (Yao, 2017)

41，Nicotinamidemononucleotide, an intermediate of NAD+ synthesis, protects the heart fromischemia and repercussion (Ya ** moto, 2014)

42，Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects theheart from ischemia and repercussion

43，Nicotinamide mononucleotide supplementation reverses vasculardysfunction and oxidative stress with aging in mice (de Picciotto, 2016)

44，Short-ter ** dministration of Nicotinamide Mononucleotide preserves cardiac mitochondrialhomeostasis and prevents heart failure (Zhang, 2017)

45，Nicotinamide mononucleotide requires SIRT3 to improve cardiacfunction and bioenergetics in a Friedreich’s ataxia cardiomyopathy model

46，Samuel W.French. Chronic alcohol binging injures the liver andother organs by reducing NAD⁺ levels required for sirtuin's deacetylaseactivity. Experimental and Molecular Pathology 100:303-306(2016)

47，NAMPT-mediatedNAD+ biosynthesis is essential for vision in mice (lin, 2016)

48，Brown KD, Maqsood S, Huang JY, Pan Y, Harkcom W, Li W, Sauve A,Verdin E, Jaffrey SR. Activation of SIRT3 by the NAD(+) precursor nicotinamideriboside protects from noise-induced hearing loss. Cell metaboli ** .2014;20:1059–1068