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转载 牛皮!此环境变量太大, 此对话框允许将值设置为最长2047个字符
解决方法自行查看原文吧(●’◡’●)https://blog.csdn.net/COCO56/article/details/102425383因为楼主的标题不包含这个问题的关键词所以搬运了一下。找的我脑袋疼,终于找到了这个超有用的方法!超有用!!!...
2019-11-26 21:53:38 691
DeepDTA_Deep Drug-Target Binding Affinity Prediction2018.pdf
DTI预测领域的高被引lw,发表于2018年.
Abstract
Motivation
The identification of novel drug–target (DT) interactions is a substantial part of the drug discovery process. Most of the computational methods that have been proposed to predict DT interactions have focused on binary classification, where the goal is to determine whether a DT pair interacts or not. However, protein–ligand interactions assume a continuum of binding strength values, also called binding affinity and predicting this value still remains a challenge. The increase in the affinity data available in DT knowledge-bases allows the use of advanced learning techniques such as deep learning architectures in the prediction of binding affinities. In this study, we propose a deep-learning based model that uses only sequence information of both targets and drugs to predict DT interaction binding affinities. The few studies that focus on DT binding affinity prediction use either 3D structures of protein–ligand complexes or 2D features of compounds. One novel approach used in this work is the modeling of protein sequences and compound 1D representations with convolutional neural networks (CNNs).
2020-03-20
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