Research Directions |
We develop novel biophotonic tomography for early-cancer detection and functional imaging, using non-ionizing electromagnetic and ultrasonic waves. Unlike ionizing x-ray radiation, non-ionizing electromagnetic waves, such as optical and radio waves, pose no health hazard and, at the same time, reveal new contrast mechanisms. For example, our spectroscopic oblique-incidence reflectometry can accurately detect skin cancers, based on their functional hemoglobin parameters and cell nuclear size. Unfortunately, electromagnetic waves in the non-ionizing spectral region do not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution tomography that is based on non-ionizing electromagnetic waves alone, as demonstrated by confocal microscopy and two-photon microscopy as well as optical coherence tomography, is limited to superficial imaging within about one optical transport mean free path (~1 mm) of the surface of biological tissue. Ultrasonic imaging, by comparison, provides good image resolution but has strong speckle artifacts as well as poor contrast in early-stage tumors. We have developed ultrasound-mediated imaging modalities by combining electromagnetic and ultrasonic waves synergistically to overcome the above problems. The hybrid modalities yield speckle-free images with high electromagnetic contrast at high ultrasonic resolution in relatively large volumes of biological tissue. Please visit the Research pages to see the specific technologies that we develop.
Job Openings |
Predoctoral Positions
Graduate research assistant (RA) positions are available in the Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis. These positions are sponsored by NIH research grants. The laboratory's research areas fall into optical imaging and ultrasound-aided biophotonic imaging, including Mueller optical coherence tomography (M-OCT), photoacoustic tomography (PAT), photoacoustic microscopy (PAM), thermoacoustic tomography (TAT), and ultrasound-modulated optical tomography (UOT). Applicants should hold a B.S. or M.S. degree in Physics, Electrical Engineering, Biomedical Engineering, Optics, Ultrasonics, or a related field. For more information regarding the research directions, please visit our home page. Interested candidates are invited to email resumes to Prof. Lihong Wang at lhwang@biomed.wustl.edu.
Postdoctoral positions
Several postdoctoral positions are immediately available in the Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis. These positions are sponsored by the National Institutes of Health. The laboratory's research areas fall into optical imaging and ultrasound-aided biophotonic imaging, including Mueller optical coherence tomography (M-OCT), photoacoustic tomography (PAT), photoacoustic microscopy (PAM), thermoacoustic tomography (TAT), and ultrasound-modulated optical tomography (UOT). Applicants should hold a doctoral degree in Physics, Electrical Engineering, Biomedical Engineering, Optics, Ultrasonics, or a related field. For more information regarding the research directions, please visit our home page. Interested candidates are invited to email a curriculum vita to Prof. Lihong Wang at lhwang@biomed.wustl.edu.
Lihong V. Wang, Ph.D.
Biography
Lihong Wang earned his Ph.D. degree at Rice University, Houston, Texas under the tutelage of Robert Curl, Richard Smalley, and Frank Tittel. He currently holds the Gene K. Beare Distinguished Professorship of Biomedical Engineering at Washington University in St. Louis. His book entitled “Biomedical Optics: Principles and Imaging,” one of the first textbooks in the field, won the 2010 Joseph W. Goodman Book Writing Award. He also edited the first book on photoacoustic tomography and coauthored a book on polarization. He has published 437 peer-reviewed articles in journals, including Nature (Cover story), Science, PNAS, and PRL, and has delivered 433 keynote, plenary, or invited talks. His Google Scholar h-index and citations have reached 107 and 45,000, respectively. His laboratory was the first to report functional photoacoustic tomography, 3D photoacoustic microscopy (PAM), photoacoustic endoscopy, photoacoustic reporter gene imaging, the photoacoustic Doppler effect, the universal photoacoustic reconstruction algorithm, microwave-induced thermoacoustic tomography, ultrasound-modulated optical tomography, time-reversed ultrasonically encoded (TRUE) optical focusing, nonlinear photoacoustic wavefront shaping (PAWS), compressed ultrafast photography (100 billion frames/s), Mueller-matrix optical coherence tomography, and optical coherence computed tomography. In particular, PAM broke through the long-standing diffusion limit on the penetration of optical microscopy and reached super-depths for noninvasive biochemical, functional, and molecular imaging in living tissue at high resolution. Dr. Wang has received 37 research grants as principal investigator, with a cumulative budget of over $47M. He is a Fellow of the AIMBE, Electromagnetics Academy, IEEE, OSA, and SPIE. He is the Editor-in-Chief of the Journal of Biomedical Optics. He chairs the annual conference on Photons plus Ultrasound, and was a chartered member of an NIH Study Section. Wang serves as the founding chairs of the scientific advisory boards of two companies which have commercialized photoacoustics. He received the NIH’s FIRST, NSF’s CAREER, NIH Director’s Pioneer, and NIH Director’s Transformative Research awards. He also received the OSA C.E.K. Mees Medal, IEEE Technical Achievement Award, IEEE Biomedical Engineering Award, and SPIE Britton Chance Biomedical Optics Award, and Senior Prize of the International Photoacoustic and Photothermal Association for “seminal contributions to photoacoustic tomography and Monte Carlo modeling of photon transport in biological tissues.” An honorary doctorate was conferred on him by Lund University, Sweden. His lab is transitioning to Caltech but plans to continue his collaborations with his current institution.
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