【365PLAN】Imperfect future immunity - 2020.11.18

Immune life history, vaccination, and the dynamics of SARS-CoV-2 over the next 5 years --- Chadi M. Saad-Roy

Humans are infected by several seasonal and cross-reacting coronaviruses. None provokes fully protective immunity, and repeat infections are the norm. Vaccines tend to be less efficient than natural infections at provoking immunity, and there are risks of adverse cross-reactions. Saad-Roy et al. used a series of simple models for a variety of immune scenarios to envisage immunological futures for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with and without vaccines. The model outcomes show that our imperfect knowledge about the imperfect coronavirus immune landscape can give rise to diverging scenarios ranging from recurring severe epidemics to elimination. It is critical that we accurately characterize immune responses to SARS-CoV-2 for translation into managing disease control.

Note_Content: The common people know few about the vaccinum. If the company issues vaccinum without performing enough experiments, what should we do? Right now, what should we do facing COVID-19?