本文介绍了利用金属纳米粒子功能化的多晶金刚石电极，通过电化学方法在含有两种不同电化学活性药物成分的环境中，对肼这一基因毒性杂质进行检测。通过改变金属纳米粒子的化学性质，可以调整肼的检测电位，从而从药物信号中选择性地筛选出肼的电流-电压响应。使用差分脉冲伏安法在静态溶液中测得，在过量对乙酰氨基酚存在下，AuNP-BDD电极对肼的检测限为11.1 μM，而PtNP-BDD电极则为3.3 μM。
摘要：
Detection of the genotoxic impurity hydrazine (HZ) in the presence of active pharmaceutical ingredients (APIs) represents a significant challenge to the pharmaceutical industry. Here we show how the use of electrochemical strategies in conjunction with metal nanoparticle (NP) functionalised polycrystalline boron-doped diamond (BDD) electrodes enables detection of HZ in the presence of two different electrochemically active APIs. By simply changing the chemical identity of the metal NP, which shifts the detection potential for HZ, it is possible to selectively screen out the API signature from the HZ current â voltage response. HZ detection limits of 11.1âµM (Au NP BDD) and 3.3âµM (Pt NP BDD) in the presence of excess acetaminophen and promazine respectively, were determined using differential pulse voltammetry in quiescent solution.
展开
扫一扫
被折叠的 条评论
为什么被折叠?
到【灌水乐园】发言
