计算机安全韩亮,韩亮

姓 名：韩亮

职称职务：副教授

联系邮箱：hanliang@suda.edu.cn

联系地址：云轩楼1325

个人简介：

一、学习工作经历

2016.5－至今苏州大学，药学院，副教授

2015.12－2016.4哈尔滨工业大学，生命科学与技术学院，副教授

2012.9－2015.12耶鲁大学，医学院，博士后

2007.9－2012.6复旦大学，药剂学，理学博士

2003.9－2007.7上海海洋大学，生物技术(海洋生物制药)，理学学士

二、研究方向

1、脑靶向递药系统；

2、脑转移瘤靶向递药系统；

三、主要成绩及研究成果

聚焦于脑靶向递药开展研究工作，作为通讯/第一作者在J Control Release、Acta Pharm Sin B、Adv Mater、Adv Funct Mater、ACS Nano、Small、Biomaterials等权威期刊发表论文19篇(1区SCI论文15篇)。主持国家自然科学基金面上项目和青年科学基金项目、江苏省自然科学基金面上项目，参编外文专著1部。担任药剂学期刊Asian J Pharm Sci青年编委。

(一)科研项目

1.国家自然科学基金面上项目(81973254)，2020.1-2023.12，主持。

2.国家自然科学基金青年科学基金项目(81703428)，2019.1-2022.12，主持。

3.江苏省自然科学基金面上项目(BK20191421)，2019.7-2022.6，主持。

4.江苏省高等学校自然科学研究面上项目(17KJB350010)，2017.9-2019.8，主持。

5.苏州市科技计划项目(SYS2019033)，2019.7-2022.6，主持。

(二)获奖荣誉

1.2020年度江苏省优秀学术学位硕士论文(郭倩)。

2.2018～2019年度苏州市自然科学优秀学术论文一等奖(缪彤彤)。

3.2018～2019年度苏州市自然科学优秀学术论文三等奖(郭倩)。

4.2017年江苏省双创博士。

5.2014年上海市研究生优秀成果(学位论文)。

(三)代表论文

1.1. Ju, Xiufeng; Miao, Tongtong; Chen, Haiyan; Ni, Jiang; Han, Liang*; Overcoming Mfsd2a-Mediated Low Transcytosis to Boost Nanoparticle Delivery to Brain for Chemotherapy of Brain Metastases, Advanced Healthcare Materials, 2021, DOI: 10.1002/adhm.202001997. (一区，IF 7.367)

2. Han, Liang*; Jiang, Chen; Evolution of blood-brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies, Acta Pharmaceutica Sinica B, 2020, DOI: 10.1016/j.apsb.2020.11.023. (一区，IF 7.097)

3. Khan, Naveed Ullah; Ni, Jiang; Ju, Xiufeng; Miao, Tongtong; Chen, Haiyan; Han, Liang*; Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment, Acta Pharmaceutica Sinica B, 2020, DOI: 10.1016/j.apsb.2020.10.015. (一区，IF 7.097)

4. Ni, Jiang; Miao, Tongtong; Su, Ma; Khan, Naveed Ullah; Ju, Xiufeng; Chen, Haiyan; Liu, Feng; Han, Liang*; PSMA-targeted nanoparticles for specific penetration of blood-brain tumor barrier and combined therapy of brain metastases, Journal of Controlled Release, 2021, 329: 934-947. (一区，IF 7.727)

5. Gao, Duo#; Zhu, Qiuning#; Ruan, Jianqing; Sun, Tao*; Han, Liang*; Polyplexes by Polymerized Dequalinium and Bifunctional Aptamer for Mitochondrial Targeting Drug Release to Overcome Drug Resistance, ACS Applied Bio Materials, 2020, 3(8): 5182-5192. (EI)

6. Miao, Tongtong; Ju, Xiufeng; Zhu, Qiuning; Wang, Yamei; Guo, Qian; Sun, Tao; Lu, Chunzhu; Han, Liang*; Nanoparticles Surmounting Blood-Brain Tumor Barrier Through Both Transcellular and Paracellular Pathways to Target Brain Metastases, Advanced Functional Materials, 2019, 29(27): 1900259. (一区，IF 16.836)

7. Guo, Qian; Zhu, Qiuning; Miao, Tongtong; Tao, Jing; Ju, Xiufeng; Sun, Zhenglong; Li, Hui; Xu, Guoqiang; Chen, Huabing; Han, Liang*; LRP1-upregulated nanoparticles for efficiently conquering the blood-brain barrier and targetedly suppressing multifocal and infiltrative brain metastases, Journal of Controlled Release, 2019, 303: 117-129. (一区，IF 7.727)

8. Dong, Aimeng#; Han, Liang#; Shao, Zhengbo; Fan, Pan; Zhou, Xinrong; Yuan, Huiping*; Glaucoma Drainage Device Coated with Mitomycin C Loaded Opal Shale Microparticles to Inhibit Bleb Fibrosis, ACS Applied Materials & Interfaces, 2019, 11(10): 10244-10253. (一区，IF 8.758)

9. Guo, Qian; Chang, Zengyan; Khan, Naveed Ullah; Miao, Tontong; Ju, Xiufeng; Feng, Huaxiang; Zhang, Lei; Sun, Zhenglong; Li, Hui; Han, Liang*; Nanosizing Noncrystalline and Porous Silica Material Naturally Occurring Opal Shale for Systemic Tumor Targeting Drug Delivery, ACS Applied Materials & Interfaces, 2018, 10(31): 25994-26004. (一区，IF 8.456)

10. Yu, Xi#; Gou, Xingchun#; Wu, Peng#; Han, Liang#; Tian, Daofeng#; Du, Fengyi; Chen, Zeming; Liu, Fuyao; Deng, Gang; Chen, Ann T.; Ma, Chao; Liu, Jun; Hashmi, Sara M.; Guo, Xing; Wang, Xiaolong; Zhao, Haitian; Liu, Xinran; Zhu, Xudong; Sheth, Kevin; Chen, Qianxue; Fan, Louzhen; Zhou, Jiangbing*; Activatable Protein Nanoparticles for Targeted Delivery of Therapeutic Peptides, Advanced Materials, 2018, 30(7): 1705383. (一区，IF 25.809)

11. Han, Liang; Kong, Derek K.; Zheng, Ming-Qiang; Murikinati, Sasidhar; Ma, Chao; Yuan, Peng; Li, Liyuan; Tian, Daofeng; Cai, Qiang; Ye, Chunlin; Holden, Daniel; Park, June-Hee; Gao, Xiaobin; Thomas, Jean-Leon; Grutzendler, Jaime; Carson, Richard E.; Huang, Yiyun; Piepmeier, Joseph M.; Zhou, Jiangbing*; Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging, ACS Nano, 2016, 10(4): 4209-4218. (一区，IF 13.942)

12. Han, Liang; Cai, Qiang; Tian, Daofeng; Kong, Derek K.; Gou, Xingchun; Chen, Zeming; Strittmatter, Stephen M.; Wang, Zuoheng; Sheth, Kevin N.; Zhou, Jiangbing*; Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles, Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 12(7): 1833-1842. (二区，IF 5.720)

13. Han, Liang; Liu, Mingming; Ye, Deyong; Zhang, Ning; Lim, Ed; Lu, Jing; Jiang, Chen*; Tumor cell membrane-targeting pH-dependent electron donor-acceptor fluorescence systems with low background signals, Biomaterials, 2014, 35(9): 2952-2960. (一区，IF 8.557)

14. Han, Liang; Guo, Yubo; Ma, Haojun; He, Xi; Kuang, Yuyang; Zhang, Ning; Lim, Ed; Zhou, Wenjiang; Jiang, Chen*; Acid Active Receptor-Specific Peptide Ligand for In Vivo Tumor-Targeted Delivery, Small, 2013, 9(21): 3647-3658. (一区，IF 7.514)

15. Han, Liang; Ma, Haojun; Guo, Yubo; Kuang, Yuyang; He, Xi; Jiang, Chen*; pH-Controlled Delivery of Nanoparticles into Tumor Cells, Advanced Healthcare Materials, 2013, 2(11): 1435-1439. (一区，IF 4.880)

16. Han, Liang; Li, Jianfeng; Huang, Shixian; Huang, Rongqin; Liu, Shuhuan; Hu, Xing; Yi, Peiwei; Shan, Dai; Wang, Xuxia; Lei, Hao; Jiang, Chen*; Peptide-conjugated polyamidoamine dendrimer as a nanoscale tumor-targeted T1 magnetic resonance imaging contrast agent, Biomaterials, 2011, 32(11): 2989-2998. (一区，IF 7.404)

17. Han, Liang; Huang, Rongqin; Li, Jianfeng; Liu, Shuhuan; Huang, Shixian; Jiang, Chen*; Plasmid pORF-hTRAIL and doxorubicin co-delivery targeting to tumor using peptide-conjugated polyamidoamine dendrimer, Biomaterials, 2011, 32(4): 1242-1252. (一区，IF 7.404)

18. Han, Liang; Huang, Rongqin; Liu, Shuhuan; Huang, Shixian; Jiang, Chen*; Peptide-Conjugated PAMAM for Targeted Doxorubicin Delivery to Transferrin Receptor Overexpressed Tumors, Molecular Pharmaceutics, 2010, 7(6): 2156-2165. (二区，IF 5.400)

19. Huang, Rongqin#; Han, Liang#; Li, Jianhua; Ren, Feiliang; Ke, Weilun; Jiang, Chen*; Pei, Yuanying; Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles, Journal of Gene Medicine, 2009, 11(9): 754-763. (三区，IF 2.968)