mysql连接提示错误_服务器经常提示mysql连接错误，有木有解决方法？

网络是联通的，因为在同一主机内，本地连接到mysql服务器，和运行环境无关，php，python连接数据库都有这种情况出现

提示Can't connect to MySQL server on 'localhost'

下面是my.ini文件内容，已经省略注释[client]

port=3306

[mysql]

default-character-set=utf8

[mysqld]

port=3306

basedir="E:/mysql/"

datadir="e:/mysql/data/"

default-character-set=utf8

default-storage-engine=MYISAM

sql-mode="STRICT_TRANS_TABLES,NO_AUTO_CREATE_USER,NO_ENGINE_SUBSTITUTION"

max_connections=5000

query_cache_size=52M

table_cache=4100

tmp_table_size=64M

thread_cache_size=64

myisam_max_sort_file_size=100G

myisam_sort_buffer_size=80M

key_buffer_size=256M

read_buffer_size=64K

read_rnd_buffer_size=256K

sort_buffer_size=16M

skip-innodb

innodb_additional_mem_pool_size=2M

innodb_flush_log_at_trx_commit=1

innodb_log_buffer_size=1M

innodb_buffer_pool_size=8M

innodb_log_file_size=10M

innodb_thread_concurrency=18

wait_timeout=28800

thread_concurrency=4

skip-locking

log-slow-queries = slow.log

long_query_time = 1

max_connections = 1000

max_allowed_packet = 32M

interactive_timeout = 28800