signature=80c2155a56b26ab6897b2c1dd670f258,6.2 Mitochondrial-Endoplasmic Reticulum Interactions

摘要：

1 IntroductionMore than 50 years of progress has provided structural details and functional consequences of the intercompartmental interactions between the mitochondrial and endoplasmic reticulum (ER) networks of eukaryotic cells. Biochemical approaches have characterized several membrane components clustered in interacting protein complexes, such as the protein import machinery of both organelles, components of the mitochondrial inner and outer membrane contact sites, division and fusion machineries of mitochondria, and most recently connections of the mitochondrial and ER networks. Moreover, the ER shares several metabolic pathways with the mitochondria: amino acid, lipid, carbohydrate, and even protein cycling exists between these two organelles, and their interrelated role in Ca2+-, ROS-, and ATP signaling is not doubted any more. In addition to playing a crucial role in the subsistence of the organelles, it has now been recognized that these complex interactions are in ...

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