一项比较高分辨率超声与微电脑断层扫描检测关节炎骨侵蚀的细致研究

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A detailed comparative study of ultrasound and high-resolution micro- computed tomography in the detection of arthritic bone erosions 1.       Stephanie Finzel1, 2.       Sarah Ohrndorf2, 3.       Matthias Englbrecht1, 4.       Christian Stach1, 5.       Janin Messerschmidt2, 6.       Georg Schett1,*,†, 7.       Marina Backhaus2 Arthritis & Rheumatism DOI: 10.1002/art.30285 Abstract Objectives: To test whether bony lesions appearing in ultrasound (US) imaging are cortical breaks detectable in micro-computed tomography (μCT) Methods: 26 individuals (14 with rheumatoid and 6 with psoriatic arthritis as well as 6 healthy controls) were assessed for bone erosions at the radial, palmar and dorsal regions of the MCP2 and the palmar and dorsal regions of the MCP3 and MCP4 joint. All patients received an US and for validation of results a μCT scan. The prevalence and severity of bone erosions obtained in US and μCT were recorded and compared. Results: Overall there was a good correlation between the severity of erosions in US and μCT (r= 0.463, p < 0.0001). False-negative (US 1/ μCT 0) results were obtained in only 10% of the joint regions and were mostly due to small erosive lesions at the dorsal sides of the MCP joints. False-positive results (US 0/ μCT 1) were more frequent (28%) and primarily based on vascular bone channels at the palmar sides of the MCP joints as well pseudo-erosions created by osteophytes. Conclusions: These data show that the majority of bone lesions obtained by US are indeed bone erosions with a cortical break. The sensitivity of US for detecting bone erosions was high and there was a good correlation between the severity of bone erosions in the US and the μCT. Specificity of US for bone erosions was substantially lower, suggesting that smaller US lesions do not always refer to breaks in the cortical bone surface.

一项比较高分辨率超声与微电脑断层扫描检测关节炎骨侵蚀的细致研究   目的: 验证超声成像（US）探测到的骨损伤是否为微电脑断层扫描(μCT)中出现的皮质破坏。 方法: 对26例个体(14例类风湿性和6例银屑病关节炎患者以及6例健康对照)的MCP2关节的桡侧、掌侧和背侧，MCP3和 MCP4关节的掌侧和背侧区域进行评估。所有病人都接受US检测和μCT的验证。对US和μCT检测到的骨侵蚀发现率和严重程度进行记录和比较。   结果: 总体上US与μCT中的骨侵蚀严重程度有很好的相关性 (r = 0.463,p < 0.0001)。只有10%的关节出现假阴性（US 1 /μCT 0)，主要原因是由于MCP关节背侧小的侵蚀性损害。假阳性结果(US 0 / μCT1)相对常见(28%)，主要原因是MCP关节掌侧的血管沟和骨赘产生的假侵蚀。 结论: 这些数据表明,US获得的大多数骨病变确实存在骨侵蚀合并骨皮质破坏。US对检测侵蚀骨的敏感性很高,US与μCT在检测骨侵蚀的严重程度上有很好的相关性。US的特异性则相对较低，提示US上小的侵蚀病变并不总是代表骨皮质表面的破坏。

转载于:https://www.cnblogs.com/T2T4RD/archive/2011/03/31/5464322.html