姓名：叶磊
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教育经历
1995.5-1999.10 Biochemistry PhD Lund University.
1985.9-1988.1 Chemical Engineering MS East China Institute of Technology.
1981.9-1985.6 BS East China Institute of Technology
博士后
1999.11-2000.12 Research associate, Pure and Applied Biochemistry, Lund University
工作经历
1988.02-1990.01 Assistant professor, Wuhan Institute of Technology, China
1990.01-1995.04 Lecturer, Wuhan Institute of Technology, China
1995.05-1995.09 Research scientist, Neoprobe Europe AB, Lund
2000.01-2004.05 Assistant professor (forskarassistent), Pure and Applied Biochemistry, Lund University
2004.06 Qualification as associate professor (docent)
2004.06-present Associate professor, time for research in the position 80%.
Duties: Research group leader, teaching undergraduate course Technical Biology and Biochemistry, supervision of PhD students, guest researchers and diploma students.
2008-present Chutian Scholar, Hubei，
研究方向
Organic chemistry (synthesis and characterization), polymer chemistry (synthesis and characterization, polymer colloids), analytical chemistry (NMR, LC-MS), biochemistry (enzymatic reactions, affinity separation, immunoassay), and multi-disciplinary research (molecular imprinting, bio-sensing).
会员
Member of the American Chemical Society and the Society for Molecular Imprinting.
杂志审稿
Peer reviewer for scientific journals: J. Am. Chem. Soc., Angew Chem. Int. Ed., Anal. Chem., Macromolecules, Chem. Mater., J. Mater. Chem., etc.
研究经费
15 funds from EU, The Swedish Research Council,NSFC
发表论文
A. Refereed publications
1) K. Yoshimatsu, J. LeJeune, D. A. Spivak, L. Ye. Peptide-imprinted polymer microspheres prepared by precipitation polymerization using a single bi-functional monomer. Analyst 2009, 134, 719-724.
2) J. Y.N. Philip, J. da C. Francisco, E. S. Dey, J. Buchweishaija, L. Mkayula, L. Ye. Isolation of anacardic acid from natural Cashew Nut Shell Liquid (CNSL) using supercritical carbon dioxide. J. Agric. Food Chem. 2008, 56, 9350-9354.
3) F. Priego-Capote, L. Ye, S. Shakil, S. A. Shamsi, S. Nilsson. Monoclonal behavior of molecularly imprinted polymer nanoparticles in capillary electrochromatography. Anal. Chem. 2008, 80, 2881-2887.
4) K. Reimhult, K. Yoshimatsu, K. Risveden, S. Chen, L. Ye, A. Krozer. Characterization of QCM sensor surfaces coated with molecularly imprinted nanoparticles. Biosens. Bioelectron. 2008, 23, 1908-1914.
5) K. Yoshimatsu, L. Ye, P. Stenlund, I. S. Chronakis. A simple method for preparation of molecularly imprinted nanofiber materials with signal transduction ability. Chem. Commun. 2008, 2022-2024.
6) K. Yoshimatsu, L. Ye, J. Lindberg, I. S. Chronakis. Selective molecular adsorption using electrospun nanofiber affinity membranes. Biosens. Bioelectron. 2008, 23, 1208-1215.
7) C. Isarankura-Na-Ayudhya, C. Nantasenamat, P. Buraparuangsang, T. Piacham, L. Ye, L. Bülow, V. Prachayasittikul. Computational insights on sulfonamide imprinted polymers. Molecules 2008, 13, 3077-3091.
8) L. Ye, K. Mosbach. Molecular imprinting: synthetic materials as substitutes for biological antibodies and receptors. Chem. Mater. 2008, 20, 859-868.
9) J. Y. N. Philip, J. Buchweishaija, L. Mkayula, L. Ye. Preparation of molecularly imprinted polymers using anacardic acid monomers derived from cashew nut shell liquid. J. Agric. Food Chem. 2007, 55, 8870-8876.
10) K. Yoshimatsu, K. Reimhult, A. Krozer, K. Mosbach, K. Sode, L. Ye. Uniform molecularly imprinted microspheres and nanoparticles prepared by precipitation polymerization: the control of particle size suitable for different analytical applications. Anal. Chim. Acta 2007, 584, 112-121.
11) C. Nantasenamat, C. Isarankura-Na-Ayudhya, L. Bülow, L. Ye, V. Prachayasittikul. In silico design for synthesis of molecularly imprinted microspheres specific towards bisphenol A by precipitation polymerization. EXCLI Journal 2006, 5, 103-117.
12) I. S. Chronakis, A. Jakob, B. Hagström and L. Ye. Encapsulation and selective recognition of molecularly imprinted theophylline and 17-estradiol nanoparticles within electrospun polymer nanofibers. Langmuir 2006, 22, 8960-8965.
13) L. Ye, K. Yoshimatsu, D. Kolodziej, J. D. C. Francisco and E. S. Dey. Preparation of molecularly imprinted polymers in supercritical carbon dioxide. J. Appl. Polym. Sci. 2006, 102, 2863-2867.
14) S. Boonpangrak, M. J. Whitcombe, V. Prachayasittikul, K. Mosbach and L. Ye. Preparation of molecularly imprinted polymers using nitroxide-mediated living radical polymerization. Biosens. Bioelectron. 2006, 22, 349-354.
15) H. Zhang, T. Piacham, M. Drew, M. Patek, K. Mosbach and L. Ye. Molecularly imprinted nanoreactors for regioselective Huisgen 1,3-dipolar cycloaddition reaction. J. Am. Chem. Soc. 2006, 128, 4178-4179.
16) T. Piacham, C. Isarankura-Na-Ayudhya, C. Nantasenamat, S. Yainoy, L. Ye, L. Bülow and V. Prachayasittikul. Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase. Biochem. Biophys. Res. Commun. 2006, 341, 925-930.
17) I. S. Chronakis, B. Milosevic, A. Frenot and L. Ye. Generation of molecular recognition sites in electrospun polymer nanofibers via molecular imprinting. Macromolecules 2006, 39, 357-361.
18) S. Boonpangrak, V. Prachayasittikul, L. Bülow and L. Ye. Molecularly imprinted polymer microspheres prepared by precipitation polymerization using a sacrificial covalent bond. J. Appl. Polym. Sci. 2006, 99, 1390-1398.
19) H. Zhang, L. Ye, K. Mosbach. Non-covalent molecular imprinting with emphasis on its application in separation and drug development. J. Mol. Recognit. 2006, 19, 248-259.
20) T. Piacham, Å Josell, H. Arwin, V. Prachayasittikul and L. Ye. Molecularly imprinted polymer thin films on quartz crystal microbalance using a surface bound photo radical initiator. Anal. Chim. Acta 2005, 536, 191-196.
21) L. Ye. Molecularly imprinted polymers for solid phase extraction and by-product removal. In: M. Yan and O. Ramström, ed. Molecularly Imprinted Materials: Science and Technology, Marcel Dekker, Inc., New York (2005) pp 603-618.
22) L. Ye, E. Yilmaz. Molecularly imprinted polymer beads. In: M. Yan and O.Ramström, ed. Molecularly Imprinted Materials: Science and Technology, Marcel Dekker, Inc., New York (2005) pp 435-454.
23) L. Ye, K. Haupt. Molecularly imprinted polymers as antibody and receptor mimics for assays, sensors and drug discovery. Anal. Bioanal. Chem. 2004, 378, 1887-1897.
24) L. Ye. Molecularly imprinted micro- and nano-particles by precipitation polymerization. Materials Research Society Symposium Proceedings 2003, 787, 97-102.
25) T. Piacham, C. I. N. Ayudhya, V. Prachayasittikul, L. Bülow, L. Ye. A polymer supported manganese catalyst useful as a superoxide dismutase mimic. Chem. Commun. 2003, 1254-1255.
26) L. Ye. Molecular imprinting: Recent developments and applications. In: Recent Research Developments in Macromolecules, 5th Ed. Research Signpost Publisher, Kerala (2003).
27) Y. Yu, L. Ye, K. Haupt, K. Mosbach. Formation of a class of enzyme inhibitors (Drugs), including a chiral compound, by using imprinted polymers or biomolecules as molecular-scale reaction vessels. Angew. Chem. Int. Ed. 2002, 41, 4459-4463.
28) Y. Yu, L. Ye, V. de Biasi, K. Mosbach. Removal of the fermentation by-product succinyl L-tyrosine from the -lactamase inhibitor clavulanic acid using a molecularly imprinted polymer. Biotech. Bioeng. 2002, 79, 23-28.
29) L. Ye, I. Surugiu, K. Haupt. Scintillation proximity assay using molecularly imprinted microspheres. Anal. Chem. 2002, 74, 959-964.
30) L. Ye, K. Mosbach. Molecularly imprinted materials: Towards the next generation. In: K.J. Shea, M.J. Roberts and M. Yan, ed. Molecularly Imprinted Materials, MRS Proceedings Volume 723, Materials Research Society, Warrendale PA, USA (2002).
31) K. Mosbach, Y. Yu, J. Andersch, L. Ye. Generation of new enzyme inhibitors using imprinted binding sites: The anti-idiotypic approach, a step towards the next generation of molecular imprinting. J. Am. Chem. Soc. 2001, 123, 12420-12421.
32) I. Surugiu, J. Svitel, L. Ye, K. Haupt, B. Danielsson. Development of a flow injection capillary chemiluminenscent ELISA using an imprinted polymer instead of the antibody. Anal. Chem. 2001, 73, 4388-4392.
33) R. Weiss, M. Janotta, L. Ye, K. Mosbach, B. Mitzaikoff. Molecularly imprinted polymers for nitrophenols: An advanced separation material for environmental analysis. Intern. J. Environ. Anal. Chem. 2001, 80, 75-86.
34) L. Ye, P. A. G. Cormack, K. Mosbach. Molecular imprinting on microgel spheres. Anal. Chim. Acta 2001, 435, 187-196.
35) L. Ye, Y. Yu, K. Mosbach. Towards the development of molecularly imprinted artificial receptors for the screening of estrogenic chemicals. Analyst 2001, 126, 760-765.
36) L. Ye, K. Mosbach. Polymers recognizing biomolecules based on a combination of molecular imprinting and proximity scintillation: a new sensor concept. J. Am. Chem. Soc. 2001, 123, 2901-2902.
37) I. Surugiu, B. Danielsson, L. Ye, K. Mosbach, K. Haupt. Chemiluminescence imaging ELISA using, instead of an antibody, an imprinted polymer as the recognition element. Anal. Chem. 2001, 73, 487-491.
38) L. Ye, K. Mosbach. The technique of molecular imprinting – Principle, state of the art, and future aspects. J. Incl. Phenom. 2001, 41, 107-113.
39) E. Yilmaz, L. Ye, K. Haupt, K. Mosbach. The use of imprinted polymers as recognition elements in biosensors and binding assays. In: Zvi Liron, Avraham Bromberg and Morly Fisher, ed. Novel Approaches in Biosensors and Rapid Diagnostic Assays, Kluwer Academic/Plenum Publishers, New York (2001).
40) L. Ye, K. Mosbach. Molecularly imprinted microspheres as antibody binding mimics. React. Funct. Polym. 2001, 48, 149-157.
41) L. Ye, R. Weiss, K. Mosbach. Synthesis and characterization of molecularly imprinted microspheres. Macromolecules 2000, 33, 8239-8245.
42) I. Surugiu, L.Ye, E. Yilmaz, A. Dzgoev, B. Danielsson, K. Mosbach, K. Haupt. An enzyme-linked molecularly imprinted sorbent assay. Analyst 2000, 125, 13-16.
43) O. Brüggemann, K. Haupt, L. Ye, E. Yilmaz, K. Mosbach. New configurations and applications of molecularly imprinted polymers. J. Chromatogr. A 2000, 889, 15-24.
44) L.Ye, K. Mosbach. The development of artificial antibodies by molecular imprinting. Proceedings for the EuroResidue IV Conference, May 8-10, 2000, Veldhoven, The Netherlands.
45) L. Ye, O. Ramström, R. J. Ansell, M.-O. Månsson, K. Mosbach. Use of molecularly imprinted polymers in a biotransformation process. Biotech. Bioeng. 1999, 64, 650-655.
46) L. Ye, P. A. G. Cormack, K. Mosbach. Molecularly imprinted monodisperse microspheres for competitive radioassay. Anal. Commun. 1999, 36, 35-38.
47) L. Ye, O. Ramström, M-O Månsson, K. Mosbach. A new application of molecularly imprinted materials. J. Mol. Recogn. 1998, 11, 75-78.
48) L. Ye, O. Ramström, K. Mosbach. Molecularly imprinted polymeric adsorbents for byproduct removal. Anal. Chem. 1998, 70, 2789-2795.
49) O. Ramström, L. Ye, M. Krook, K. Mosbach. Screening of a combinatorial steroid library using molecularly imprinted polymers. Anal. Commun. 1998, 35, 9-11.
50) O. Ramström, L. Ye, P-E Gustavsson. Chiral recognition by molecularly imprinted polymers in aqueous media. Chromatographia 1998, 48, 197-202.
51) O. Ramström, L. Ye, M. Krook, K. Mosbach. Applications of molecularly imprinted materials as selective adsorbents: Emphasis on enzymatic equilibrium shifting and library screening. Chromatographia 1998, 47, 465-469.
52) O. Ramström, L. Ye, K. Mosbach. Artificial antibodies to corticosteroids prepared by molecular imprinting. Chem. Biol. 1996, 3, 471-477.
53) L. Ye, Z. Wang. Organic fluorescent pigment and their application in coatings. Coatings Industry 1995, 5, 33-35.
B. Patents and patent applications
1. Customized molecularly imprinted polymer (MIP) units. Swedish patent application Nr. 0950083-6.
2. Scintillation fibers by electrospinning. Swedish patent application Nr. 0800231-3.
3. Monoclonal molecularly imprinted nanoparticles. Swedish patent application Nr. 0600142-4.
4. Molecular imprinting recognition sites of electrospun polymer micro/nanofibers. Swedish patent SE 530536.
5. Generation of compound libraries utilizing molecular imprints including a double or anti-idiotypic imprinting. WO 03/27047.
6. Process for clavulanic acid purification using molecular imprinted polymers. US patent US 7087748.
7. Molecularly imprinted scintillation polymers. WO 02/68958.
8. Molecularly imprinted microspheres prepared using precipitation polymerisation. WO 00/41723.
9. Materials for screening of combinatorial libraries. WO 99/33768.
C. Conference contributions
1. J. Y. N. Philip, L. Ye. Insight into molecular imprinting process in precipitation polymerization systems using solution 1H NMR technique. The 5th International Workshop on Molecular Imprinting (September 7-12, 2008, Kobe, Japan)
2. K. Yang, C. Zhao, L. Ye. Synthesis and characterization of molecularly imprinted nanoparticles prepared by distillation precipitation polymerization. The 5th International Workshop on Molecular Imprinting (September 7-12, 2008, Kobe, Japan)
3. J. Y. N. Philip, J. Buchweishaija, L. Mkayula, L. Ye The influence of aliphatic side chain of anacardic acid on molecular recognition properties of imprinted polymers. The 5th International Workshop on Molecular Imprinting (September 7-12, 2008, Kobe, Japan)
4. K. Yoshimatsu, L. Ye, D. A. Spivak, Jason LeJeune. Molecularly imprinted polymer beads for selective C- and N-terminal recognition of oligopeptides. The 5th International Workshop on Molecular Imprinting (September 7-12, 2008, Kobe, Japan)
5. K. Yoshimatsu, L. Ye. Preparation of molecularly imprinted polymers for progesterone recognition. The 5th International Workshop on Molecular Imprinting (September 7-12, 2008, Kobe, Japan)
6. L. Ye. Molecularly imprinted nanoparticles, microbeads and fibrous structures: from fundamentals to real applications. The 5th International Workshop on Molecular Imprinting (September 7-12, 2008, Kobe, Japan)
7. K. Yoshimatsu, L. Ye, D. A. Spivak, Jason LeJeune. Molecularly imprinted polymer microspheres (spherical OMNiMIPs) prepared by precipitation polymerization using a single bifunctional monomer. The 236th ACS National Meeting (August 17-21, 2008, Philadelphia, PA, USA)
8. K. Yoshimatsu, L. Ye, J. Lindberg, I. S. Chronakis. Biomimetic nanocomposites with selective molecular adsorption using electrospun nanofiber affinity membranes. The 13th European Conference on Composite Materials (June 2-5, 2008, Stockholm, Sweden)
9. K. Yoshimatsu, L. Ye. Preparation and analytical application of molecularly imprinted nanoparticles and nanofibers. The 59th Pittshurgh Conference on Analytical Chemistry and Applied Spectroscopy – PITTCON 2008 (March 1-7, 2008, New Orleans, USA)
10. L. Ye, K. Yoshimatsu, J. Lindberg, I. S. Chronakis. Composite electrospun nanofibers containing imprinted nanoparticles for biotechnology applications. MaterialsToday ASIA (September 3-5, 2007, Beijing, China)
11. K. Yoshimatsu, L. Ye, J. Lindberg, I. S. Chronakis. Preparation and analytical applications of molecularly imprinted nanoparticles and nanofibers. The 41st IUPAC Congress: Chemistry Protecting Health, Natural Environment, and Cultural Heritage (August 5-10, 2007, Torino, Italy)
12. L. Ye, K. Yoshimatsu, J. Lindberg, I. S. Chronakis. Composite electrospun nanofibers containing imprinted nanoparticles for biotechnology applications. MaterialsToday ASIA (September 3-5, 2007, Beijing, China)
13. K. Yoshimatsu, L. Ye, J. Lindberg, I. S. Chronakis. Preparation and analytical applications of molecularly imprinted nanoparticles and nanofibers. The 41st IUPAC Congress: Chemistry Protecting Health, Natural Environment, and Cultural Heritage (August 5-10, Torino, Italy)
14. L. Ye, K. Yoshimatsu, J. Lindberg, I. S. Chronakis. Composite electrospun nanofibers containing imprinted nanoparticles for molecular recognition. The 15th International Conference on Composites/Nano Engineering (July 15-21, 2007, Haikou, China)
15. K. Yoshimatsu, P. Svensson, S. A. Eremin, L. Ye. Towards fluorescent drug assays using molecularly imprinted nanoparticles. The 12th International Symposium on Luminescence Spectrometry: Detection Techniques in Biomedical, Environmental and Food Analysis (July 18-21, 2006, Lugo, Spain)
16. K. Yoshimatsu, L. Ye, J. Lindberg, I. S. Chronakis. Electrospun nanofiber membranes containing molecularly imprinted nanoparticles. The 4th International Workshop on Molecular Imprinting (September 10-14, 2006, Cardiff, UK)
17. L. Ye, F. Priego-Capote, S. Shakil, A. A. Shamsi, S. Nilsson. Monoclonal behavior of molecularly imprinted polymer nanoparticles in capillary electrochromatography. The 4th International Workshop on Molecular Imprinting (September 10-14, 2006, Cardiff, UK)
18. K. Reimhult, K. Yoshimatsu, L. Ye, A. Krozer. Analyzing molecularly imprinted polymers using quartz crystal microbalance. The 4th International Workshop on Molecular Imprinting (September 10-14, 2006, Cardiff, UK)
19. N. Haj-Hosseinia, C. Rusu, A. Krozer, S. Hassl, B. Ottosson, K. Reimhult, P. Enoksson, L. Ye. Characterisation of molecularly imprinted polymers (MIPs) for biosensors. Micro Structure Workshop 2006 (May 9-10, 2006, V?ster?s, Sweden)
20. N. Haj-Hosseinia, K. Reimhult, A. Krozer, P. Enoksson, L. Ye. Preparation of molecularly imprinted polymers (MIPs) using electropolymerisation. Life is matter – life matters: Conversations in bionanotechnology (October 25-27, 2005, G?teborg, Sweden)
21. K. Yoshimatsu, A. Krozer, K. Sode, L. Ye. Preparation of monodisperse propranolol-imprinted microspheres by precipitation polymerization. Synthetic Receptors 2005: The Second World Congress on Synthetic Receptors (September 7-9, 2005, Salzburg, Austria)
22. S. Boonpangrak, M. J. Whitcombe, V. Prachayasittikul, K. Mosbach, Lei Ye. Preparation of molecularly imprinted polymers using nitroxide-mediated living radical polymerization. Synthetic Receptors 2005: The Second World Congress on Synthetic Receptors (September 7-9, 2005, Salzburg, Austria)
23. K. Mosbach, L. Ye and H. Zhang. Nano imprint biotechnology. AFFINITY 2005: the 16th biennial meeting of the international society for molecular recognition (August 14-18, 2005, Uppsala, Sweden)
24. L. Ye, H. Zhang, K. Yoshimatsu, K. Mosbach. Molecular imprints as synthetic receptors and their applications. Trends in Organic Chemistry: Synthetic Receptors (June 13, 2005, Lund, Sweden)
25. T. Piacham, ?. Josell, H. Arwin, V. Prachayasittikul, L. Ye. Molecularly imprinted polymer thin films on quartz crystal microbalance using a surface bound photo radical initiator. The 3rd International Workshop on Molecular Imprinting (September 12-15, 2004, Cardiff, UK)
26. S. Boonpangrak, V. Prachayasittikul, L. Bülow, L. Ye. Molecularly imprinted polymer microspheres by precipitation polymerization using a sacrificial covalent bond. Lei Ye, The 3rd International Workshop on Molecular Imprinting (September 12-15, 2004, Cardiff, UK)
27. L. Ye. Molecularly imprinted micro- and nano-particles by precipitation polymerization. Materials Research Society Symposium 2003 Fall Meeting (December 1-5, Boston, USA)
28. L. Ye. Molecular imprinting in connection with dynamic combinatorial library. The 8th International symposium on polymer designs for bioseparation and nanobiotechnology (November 27-29, Compiègne, France)
29. L. Ye, T. Piacham, V. Prachayasittikul, L. Bülow. Polymer supported manganese catalyst as superoxide dismutase mimic. Europolymer Congress 2003 (June 23-27, 2003, Stockholm, Sweden)
30. L. Ye, K. Mosbach. Molecularly imprinted polymers in (bio)chemical synthesis and biomimetic sensors. IUPAC World Polymer Congress 2002 and 39th International Symposium on Macromolecules (July 7-12, 2002, Beijing, China)
31. L. Ye, Y. Yu, K. Mosbach. Molecularly imprinted polymers in (bio)chemical synthesis and biomimetic sensors. The 2nd International Workshop on Molecular Imprinting (September 15-19, 2002, La Grande Motte, France)
32. L. Ye, K. Mosbach. Molecularly imprinted materials: Towards the next generation. Materials Research Society Symposium 2002 Spring Meeting (April 1-5, 2002, San Francisco, USA)
33. L. Ye, K. Mosbach. The technique of molecular imprinting – Principle, state of the art, and future aspects. The 26th International Symposium on Macrocyclic Chemistry (July 15-20, 2001, Fukuoka City, Japan)
34. L. Ye, K. Mosbach. Molecularly imprinted polymers: Some new developments in preparation methods and applications.The 6th International Symposium on Polymers for Advanced Technologies (Sept. 2-6, 2001, Eilat, Israel)
35. L. Ye, K. Mosbach. Molecular imprinting on microgel spheres. The 1st International Workshop on Molecular Imprinting (July 3-5, 2000, Cardiff, UK)
36. L. Ye, K. Mosbach. Molecularly imprinted microspheres as antibody binding mimics. IUPAC 9th International Conference on Polymer Based Technology (May 21-26, 2000, Tianjin, China)
37. E. Yilmaz, L. Ye, K. Haupt, K. Mosbach. The use of imprinted polymers as recognition elements in biosensors and binding assays. The 43rd OHOLO Conference on Novel Approaches in Biosensors and Rapid Diagnostic Assays (October 10-14, 1999, Eilat, Israel)
38. O. Ramström, L. Ye, P.-E. Gustavsson. Recent advances in the use of molecularly imprinted materials in separation and synthesis. The 213th National Meeting of the American Chemical Society (April 13-17, 1998, San Francisco, USA)
39. L. Ye, M.-O. Månsson, K. Mosbach, O. Ramström. New applications of molecularly imprinted materials. The 12th International Symposium on Affinity Interactions: Fundamentals and Applications of Biomolecular Recognition (June 15-19, 1997, Kalmar, Sweden)
40. L. Ye, W. Zhu. Research on polyacrylate-polyurethane coatings containing Interpenetrating Polymer Networks. The Annual Symposium of the Chinese Surface Engineering Society (1993, Guangdong, China).
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