solaris matlab,MATLAB在医学中的应用.ppt

MATLAB在医学中的应用;内容：;机能核磁共振成像;fMRI Setup – what it really looks like!;Magnet Safety;fMRI Setup;fMRI Experiment Stages: Prep;fMRI Experiment Stages: Anatomical;Slice Thicknesse.g., 6 mm;fMRI Experiment Stages: Functional;Statistical Mapsuperimposed on anatomical MRI image;fMRI Physics ;History of Nuclear Magnetic Resonance;Physics of protons.;Protons aligning within a magnetic field;Larmor Frequency;Reading M0;Magnet;Step 1: Put Subject in Big Magnet;source: ;Step 3: Measure Radio Waves;sinuses;The BOLD Contrast;BOLD signal;The Haemodynamic Response Function (HRF);Physiology of the BOLD signal;BOLD seems to be correlated to postsynaptic activity;How does the BOLD reflect the energy demands of the brain?;SPM (Statistical Parametric Mapping);Statistical Parametric Mapping…a voxel by voxel hypothesis testing approachreliably identify regions showing a significant experimental effect of interestType I errorsignificance test at each voxelmodel voxel data, test parametersno exact prior anatomical hypothesismultiple comparisonsGeneral Linear ModelRandom field theorySPM…the software;SPM’99 GUI…;Spatial realignment, spatial normalisation, segmentation, coregistration, spatial smoothingStatisticalvoxel by voxel statistical analysisgeneral linear model, generalised for temporal autocorrelationrandom effects analysesmultiple comparisons: Corrected p-values from random field theoryplotting & results interrogationUtilitiesimage display, CheckReg, rendering, brain extraction, adjusted means, image algebra;SPM history…;SPM architecture;Workstationdeveloped on Sun Solaris UNIXSolaris, Linux & Windows supportedother UNIXdisk & memory…Matlab 5.3.0 or laterno special “toolboxes” requiredSPM’99 won’t work with Matlab 4ANSII C Compilerto compile external C–mex routinesready for Solaris, Linux, & WindowsAnalyze / MINC format imagesconversion programextend SPMInternet access…for SPMweb & the email discussion listPlenty of time!;SPM resources…;SPM documen