本文介绍了一种自动化组织微阵列成像系统，该系统包括组织微阵列、机器人显微镜和成像工作站。系统能够自动控制显微镜捕捉图像并分析样本，使用低倍镜定位，高倍镜进行详细分析。多染料技术可用于独立测量和分析每个样本的染色强度，图像和量化数据存储在关系数据库中，支持本地或Web方式的远程控制和结果共享。
摘要：
A tissue microarray imaging system autonomously images, analyzes, and stores data for samples in a tissue microarray. The system may include a tissue microarray, a robotic microscope, and an imaging workstation that executes software to automatically control operation of the microscope to capture images from the microarray and analyze image results. A low magnification may be used to register samples within the microarray and obtain coordinates for each tissue specimen. Progressively higher magnifications may be used to analyze images of each registered specimen. Where multiple dyes are used to stain specimens, color separation techniques may be applied to independently measure and analyze each staining intensity. Images and quantitative data from the images may then be stored in a relational database for subsequent review. The system may be local, or may be Web-based for distributed control and sharing of results.
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