druid连接mysql 无法获取到数据_长时间运行下JPA无法获取druid数据库连接

项目上线运行每当几天后就出现无法获取到 数据库 连接，头几天运行都还正常。

日志打印

org.springframework.orm.jpa.JpaSystemException: Unable to acquire JDBC Connection; nested exception is org.hibernate.exception.GenericJDBCException: Unable to acquire JDBC Connection

at org.springframework.orm.jpa.vendor.HibernateJpaDialect.convertHibernateAccessException(HibernateJpaDialect.java:333) ~[spring-orm-4.3.5.RELEASE.jar:4.3.5.RELEASE]

at org.springframework.orm.jpa.vendor.HibernateJpaDialect.translateExceptionIfPossible(HibernateJpaDialect.java:241) ~[spring-orm-4.3.5.RELEASE.jar:4.3.5.RELEASE]

at org.springframework.orm.jpa.AbstractEntityManagerFactoryBean.translateExceptionIfPossible(AbstractEntityManagerFactoryBean.java:491) ~[spring-orm-4.3.5.RELEASE.jar:4.3.5.RELEASE]

at org.springframework.dao.support.ChainedPersistenceExceptionTranslator.translateExceptionIfPossible(ChainedPersistenceExceptionTranslator.java:59) ~[spring-tx-4.3.5.RELEASE.jar:4.3.5.RELEASE]

at org.springframework.dao.support.DataAccessUtils.translateIfNecessary(DataAccessUtils.java:213) ~[spring-tx-4.3.5.RELEASE.jar:4.3.5.RELEASE]

at org.springframework.dao.support.PersistenceExceptionTranslationInterceptor.invoke(PersistenceExceptionTranslationInterceptor.java:147) ~[spring-tx-4.3.5.RELEASE.jar:4.3.5.RELEASE]

at org.springframework.aop.framework.ReflectiveMethodInvocation.proceed(ReflectiveMethodInvocation.java:179) ~[spring-aop-4.3.5.RELEASE.jar:4.3.5.RELEASE]

at org.springframework.data.jpa.repository.support.CrudMethodMetadataPostProcessor$CrudMethodMetadataPopulatingMethodInterceptor.invoke(CrudMethodMetadataPostProcessor.java:133) ~[spring-data-jpa-1.10.5.RELEASE.jar:?]

at org.springframework.aop.framework.ReflectiveMethodInvocation.proceed(ReflectiveMethodInvocation.java:179) ~[spring-aop-4.3.5.RELEASE.jar:4.3.5.RELEASE]

at org.springframework.aop.interceptor.ExposeInvocationInterceptor.invoke(ExposeInvocationInterceptor.java:92) ~[spring-aop-4.3.5.RELEASE.jar:4.3.5.RELEASE]

at org.springframework.aop.framework.ReflectiveMethodInvocation.proceed(ReflectiveMethodInvocation.java:179) ~[spring-aop-4.3.5.RELEASE.jar:4.3.5.RELEASE]

at org.springframework.aop.framework.JdkDynamicAopProxy.invoke(JdkDynamicAopProxy.java:213) ~[spring-aop-4.3.5.RELEASE.jar:4.3.5.RELEASE]

at com.sun.proxy.$Proxy223.findOne(Unknown Source) ~[?:?]

at com.isesol.orm.jpa.AbstractJpaEntityManager.findOne(AbstractJpaEntityManager.java:93) ~[isesol-orm-jpa-1.0.0.jar:1.0.0]

at com.isesol.orm.jpa.AbstractJpaEntityManager.findOne(AbstractJpaEntityManager.java:100) ~[isesol-orm-jpa-1.0.0.jar:1.0.0]

at com.isesol.orm.jpa.AbstractJpaEntityManager$$FastClassBySpringCGLIB$$3a5951f4.invoke() ~[isesol-orm-jpa-1.0.0.jar:1.0.0]

at org.springframework.cglib.proxy.MethodProxy.invoke(MethodProxy.java:204) ~[spring-core-4.3.5.RELEASE.jar:4.3.5.RELEASE]

at org.springframework.aop.framework.CglibAopProxy$DynamicAdvisedInterceptor.intercept(CglibAopProxy.java:652) ~[spring-aop-4.3.5.RELEASE.jar:4.3.5.RELEASE]

at com.isesol.rent.platform.manager.TRentLogBizDefineManager$$EnhancerBySpringCGLIB$$3355bf68.findOne() ~[rent-core-2.4.2-SNAPSHOT.jar:2.4.2-SNAPSHOT]

at com.isesol.rent.platform.interceptor.RentBizLogInterceptor.execute(RentBizLogInterceptor.java:41) [rent-core-2.4.2-SNAPSHOT.jar:2.4.2-SNAPSHOT]

at com.isesol.api.rest.cgi.interceptor.AbstractRestRequestInterceptor.execute(AbstractRestRequestInterceptor.java:43) [isesol-rest-extension-1.0.0-SNAPSHOT.jar:1.0.0-SNAPSHOT]

at com.isesol.api.rest.cgi.utils.RestHelpers.returnResponse(RestHelpers.java:98) [isesol-rest-extension-1.0.0-SNAPSHOT.jar:1.0.0-SNAPSHOT]

at com.isesol.api.rest.cgi.utils.RestServiceUtils.invokePrepareInterceptors(RestServiceUtils.java:369) [isesol-rest-extension-1.0.0-SNAPSHOT.jar:1.0.0-SNAPSHOT]

at com.isesol.api.rest.web.cgi.RestServiceController.handleRequest(RestServiceController.java:220) [isesol-rest-extension-1.0.0-SNAPSHOT.jar:1.0.0-SNAPSHOT]

at sun.reflect.GeneratedMethodAccessor673.invoke(Unknown Source) ~[?:?]

at sun.reflect.DelegatingMethodAccessorImpl.invoke(DelegatingMethodAccessorImpl.java:43) ~[?:1.8.0_92]

at java.lang.reflect.Method.invoke(Method.java:498) ~[?:1.8.0_92]

at org.springframework.web.method.support.InvocableHandlerMethod.doInvoke(InvocableHandlerMethod.java:220) [spring-web-4.3.5.RELEASE.jar:4.3.5.RELEASE]

at org.springframework.web.method.support.InvocableHandlerMethod.invokeForRequest(InvocableHandlerMethod.java:134) [spring-web-4.3.5.RELEASE.jar:4.3.5.RELEASE]

at org.springframework.web.servlet.mvc.method.annotation.ServletInvocableHandlerMethod.invokeAndHandle(ServletInvocableHandlerMethod.java:116) [spring-webmvc-4.3.5.RELEASE.jar:4.3.5.RELEASE]

at org.springframework.web.servlet.mvc.method.annotation.RequestMapping