依达奴林，RG7388 抑制剂，Idasanutlin，MDM2是p53通路的负调控因子

文章关键词：RG7388 抑制剂，依达奴林，Idasanutlin，1229705-06-9

——————基本信息——————

性质简介：RG7388， Also known as Idasanutlin, it is a highly selective MDM2 antagonist that has attracted widespread attention in recent years. It restores the stability and transcriptional activity of p53 by blocking the interaction between MDM2 protein and cell inhibitory protein p53, thereby inducing cell apoptosis. As an MDM2 antagonist, RG7388's core mechanism of action is to block the interaction between MDM2 protein and p53. MDM2 is a zinc finger nuclear phosphoprotein that is a negative regulator of the p53 pathway. It is often overexpressed in cells and is closely related to cell proliferation and survival. RG7388 inhibits the ubiquitination degradation of p53 by binding to MDM2 protein, thereby maintaining the stability of p53. Stable p53 can restore its transcriptional activity, thereby activating the expression of a series of downstream genes, leading to cell cycle arrest and apoptosis, ultimately inhibiting cell growth and diffusion.

中文名：RG7388 抑制剂，依达奴林

英文名：Idasanutlin

CAS号：1229705-06-9

化学式：C31H29Cl2F2N3O4

分子量：616.48200

结构式：

 

​——————详情介绍——————

规格：1g、5g、10g

纯度：95%+

储存条件：本品应密封避光，储存于阴凉、干燥、通风处，避免反复冻融，储液应该立即使用

注意事项：试剂仅用于科学研究或者工业应用等非医疗目的，非药用，非食用！

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